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Issues in Risk Assessment (1993) / Chapter Skim
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ANNEX C: ADJUSTMENT OF POTENCY VALUES FOR LESS THAN LIFETIME EXPOSURE
Pages 164-165

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From page 164...
... This effectively scales the TD50 values to a standard two year rodent lifetime. Specifically, we have where the TD50 denotes the estimate of carcinogenic potency based on the observed data for the actual experimental period, and denotes the standardized value.
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From page 165...
... In our applications of the Weibull model in (A.1) , we will use a similar adjustment factor of f2/k to standardize TD50 values to a two year rodent lifetime.
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Key Terms

  • adjustment factor
  • observations reported
  • actual experimental
  • experimental period
  • similar adjustment

  • observed data
  • print version
  • empirical observations
  • carcinogenic potency
  • potency based

  • applications considered
  • authoritative version
  • standardized value
  • rodent lifetime
  • study period

  • observations falling
  • observed values
  • variability based
  • extended weibull
  • effectively scales

  • correct dispersion
  • period encompassed
  • multiplicative factor
  • distinct times
  • trimmed mean

  • potency values
  • lifetime exposure


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