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Issues in Risk Assessment (1993) / Chapter Skim
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ANNEX D: CORRELATION BETWEEN TD50 AND MTD
Pages 166-168

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From page 166...
... The estimate of β is appropriate for r ≤ x ≤ n-1. The lower limit of x = r is the minimum value of x that would lead to a statistically significant result at a nominal significance level of 0 < γ < 1; the value of r is determined from the fact that in the absence of a treatment effect at dose D, x follows the binomial distribution Bin (50, P(D)
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From page 167...
... Please use the print version of this publication as the authoritative version for attribution. whereas x ≤ r implies We wish to find the correlation between Y = logeTD50 and X = log eD.
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From page 168...
... Please use the print version of this publication as the authoritative version for attribution. and APPENDIX F Thus we have where µ = E(X)
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Key Terms

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  • natural logarithms
  • x follows
  • response rate
  • print version

  • significant result
  • empirical distribution
  • animal exposed
  • using logarithms
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  • tumor occurring
  • minimum value
  • simpler using
  • treatment effect
  • spontaneous response

  • mtd satisfies
  • significance level
  • using natural
  • approximately normal
  • authoritative version

  • statistically significant
  • binomial distribution
  • whereas x
  • constraint x
  • uniform distribution

  • lower limit
  • develop tumors
  • animals exposed
  • correlation coefficient
  • shape parameter


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