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Issues in Risk Assessment (1993) / Chapter Skim
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CRITERIA AND CANDIDATE CHEMICALS
Pages 175-176

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From page 175...
... For purposes of discussion, we refer to these hypothetically excluded carcinogens that properly belong in Region C as "supercarcinogens" -- defined for this purpose as carcinogens whose TD50s lie below the 95% error bound on the regression line in Figure 1, i.e., less than about MTD/7. One hypothetical source of bias is that some of these agents were identified as potent carcinogens long ago and, being well known as such, were never tested in up-to-date bioassays and so did not have met the inclusion criteria of the CPDB.
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From page 176...
... Direct Brown 95 B Dibenz[a,h] anthracene A Dimethyl sulfate C Ethylene dibromide B Ethylene oxide E Ethylnitrosourea C Methyl bromide B MOCA E Plutonium A,B,C,D, (most potent member of class of radionuclides)
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Key Terms

  • inclusion criteria
  • various criteria
  • candidate agents
  • unusually wide
  • calculation procedures

  • committee selected
  • print version
  • hypothetically excluded
  • following criteria
  • parent compound

  • ethylene oxide
  • dimethyl sulfate
  • direct brown
  • identify candidate
  • lie below

  • benzidine dyes
  • error bound
  • systematic compilation
  • methyl bromide
  • regression line

  • necessarily informal
  • potent carcinogens
  • properly belong
  • ethylene dibromide
  • excluded carcinogens

  • authoritative version
  • committee conducted
  • hypothetical source
  • hypothetical biases
  • wide range


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