Issues in Risk Assessment (1993) / Chapter Skim
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BIOLOGIC CONSIDERATIONS
BIOLOGIC CONSIDERATIONS
Pages 188-189
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From page 188... ...
BIOLOGIC CONSIDERATIONS Clinicians and pathologists have long recognized that cancer formation in humans is often preceded by a series of preneoplastic changes. Confirmation of the multistage nature of certain human cancers has been obtained by studies of the role of changes in oncogenes and suppressor genes in human colon cancer (Hollstein et al., 1991)
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From page 189... ...
Other possible target genes, such as the genes that contribute to cell division cycles or the genes that affect the microenvironment in which developing cancer cell clones might be inhibited or selectively enhanced, have received less attention. It is generally assumed, too, that cell proliferation in general increases the probability of inheritance of random mutations by somatic cells, thus contributing indirectly to the carcinogenic process (Cohen et al., 1991)
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