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Issues in Risk Assessment (1993) / Chapter Skim
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Pages 212-212

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From page 212...
... As the chlordane example illustrates, alternative functional forms that fit the data in the experimental range can lead to widely differing estimates of risk in the low dose range. Narrowing the uncertainty in the low dose range will require improved mechanistic understanding of how exposure to low doses of a toxicant affects the kinetics of cell transformation and proliferation.
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Key Terms

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  • biologically based

  • predicted zero
  • chlordane example
  • alternative functional
  • bioassay data
  • distribution function

  • zero incremental
  • model fails
  • particular biologic
  • characterize accurately
  • widely differing

  • cumulative distribution
  • cancer risk
  • applying biologically
  • functional forms
  • mechanistic understanding

  • biologic parameter
  • model parameters
  • require improved
  • improved mechanistic
  • dose below

  • differing estimates
  • incremental cancer
  • example illustrates
  • based models
  • formal statistical


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