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Issues in Risk Assessment (1993) / Chapter Skim
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CONCLUSIONS AND RECOMMENDATIONS
Pages 215-216

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From page 215...
... CONCLUSIONS AND RECOMMENDATIONS Mechanistic understanding of toxicity has strong implications for improvement in the development of low dose extrapolation for the regulation of chemical substances. Currently, low dose extrapolation uses a multistage model with data developed from human occupational exposures or from whole animal bioassays (Anderson et al., 1983)
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From page 216...
... Although the committee recognizes that the simulation approach to model fitting can have very important uses, particularly for exploratory data analysis and when no closed form solution of the two-stage model is available, the committee recommends that whenever the model is applied in formal risk assessment, formal statistical methods (e.g., maximum likelihood) should be employed.
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Key Terms

  • sufficient data
  • low dose
  • dose extrapolation
  • cell birth
  • management context

  • recommendations mechanistic
  • sufficient mechanistic
  • biologically based
  • related quantitative
  • investigative techniques

  • formal risk
  • print version
  • health importance
  • human occupational
  • multistage model

  • exploratory data
  • sensitivity analyses
  • form solution
  • strong implications
  • exploratory applications

  • occupational exposures
  • death data
  • critical assumptions
  • rapid development
  • interval methods

  • recommends exploratory
  • based mathematical
  • data developed
  • biologic investigative
  • formal statistical


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