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Issues in Risk Assessment (1993) / Chapter Skim
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QUANTITATIVE INFORMATION
Pages 49-52

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From page 49...
... Knowledge about the quantitative response obtained in the bioassay enables scientists to make estimates of relative carcinogenic potency and adds information beyond the simple identification of a substance as a likely carcinogen or noncarcinogen. Current bioassays that use the MTD and one or two lower doses provide some limited information about the shape of the high dose portion of the dose response curve.
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From page 50...
... It is important to note that the linear relationship cannot be verified directly, nor can it be verified that the estimate so computed provides a true upper bound on risk at very low doses. Nevertheless, the linearized multistage procedure has been widely used by regulatory agencies and is thought to provide an objective basis for decisions concerning regulation of chemicals found, in high dose bioassays, to increase tumor frequencies in animals.
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From page 51...
... and many pharmaceutical exposures. In these cases, the human dose rates are very similar to those used in rodent bioassays, and the focus of supplementary testing would be to elucidate biologic mechanisms to determine the human relevance of bioassay results, not the validity of low dose extrapolation.
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From page 52...
... Please use the print version of this publication as the authoritative version for attribution.ADVANTAGES AND DISADVANTAGES OF BIOASSAYS THAT USE THE MTD 52
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Key Terms

  • lower doses
  • dose selection
  • low doses
  • low dose
  • bioassay results

  • toxic responses
  • induced cell
  • cell proliferation
  • biologic mechanisms
  • dose risk

  • human dose
  • dose exposures
  • provide little
  • human exposures
  • published bioassay

  • dose occupational
  • bioassay enables
  • toxic effects
  • current standard
  • dose rates

  • dose bioassays
  • experimental doses
  • provide supporting
  • bioassays provide
  • doses provide

  • dose tested
  • dose extrapolation
  • mtd yields
  • animal studies
  • increase tumor


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