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Issues in Risk Assessment (1993) / Chapter Skim
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OPTION 3
Pages 55-56

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From page 55...
... Although implementation of this option would identify primarily Region C carcinogens, there is little evidence that Region C carcinogens contribute a predominant portion of chemically induced cancer risk to human populations. Future uses of a chemical cannot always be anticipated.
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From page 56...
... For example, if human populations were reasonably expected to encounter high concentrations of the test substance, the MTD would continue to be used. In many cases, however, the HDT would be lower than the MTD as currently defined, and the spacing of doses could be much wider than commonly adopted by programs such as the National Toxicology Program (NTP)
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Key Terms

  • carcinogenic potency
  • physiologic change
  • human populations
  • cancer risk
  • quantitative measurements

  • national toxicology
  • preliminary studies
  • physiologic changes
  • mechanisms underlying
  • predominant portion

  • serum enzyme
  • hazardous substances
  • print version
  • underlying responses
  • current evidence

  • induced cancer
  • chloride workers
  • human risk
  • commonly adopted
  • potentially hazardous

  • physiologic effects
  • produce toxicity
  • preliminary data
  • expected exposures
  • responses observed

  • toxicology program
  • pharmacokinetic studies
  • substances themselves
  • evaluate preliminary
  • observed carcinogenic


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