Issues in Risk Assessment (1993) / Chapter Skim
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Option 4A
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Pages 57-58
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From page 57... ...
The animal bioassay that uses the MTD is one part of a complete program for identifying human carcinogens. It generally is conducted after some indication that a substance merits examination -- e.g., information that a chemical has a structural similarity to a known carcinogen, results of a test for mutagenicity, or a suggestion that there will be extensive human exposure to the substance.
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From page 58... ...
do not add greatly to our ability to make regulatory decisions because of the uncertainty about the human implications of positive results in animal bioassays. Chemicals could be chosen for full testing on the basis of expected human exposures, importance in commerce, structural similarity to a known carcinogen, or results of mutagenicity tests -- i.e., in much the same way that chemicals are currently chosen for testing.
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