Issues in Risk Assessment (1993) / Chapter Skim
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Option 4B
Option 4B
Pages 59-60
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From page 59... ...
Relatively simple pharmacokinetic studies could determine the approximate dose that exceeds the ability of an animal to absorb and metabolize the test chemical. The usefulness of such data in the design of a long-term study can be illustrated by the pharmacokinetics of inhaled methyl bromide (Medinsky et al., 1985)
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From page 60... ...
Additional work might include more detailed pharmacokinetic studies, such as studies of the effect of dose on the kinetics of specific metabolic pathways and the identification of metabolites; studies of the effects of the test chemical on primary physiologic control systems, such as the endocrine, renal, and cardiovascular systems; studies of the effects on growth-regulating systems in target organs and cells (such as perturbation of oncogene products, alteration of protein kinases, activation of cytokines, and alteration of hormones) ; studies of mechanisms of mutagenesis; and studies of the induction or reduction of detoxifying enzyme systems.
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