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Issues in Risk Assessment (1993) / Chapter Skim
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THE TWO-STAGE MODEL OF CARCINOGENESIS
Pages 9-9

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From page 9...
... Current evidence suggests that some tumors might require more than two critical events to be expressed as human cancer. More complex models might be needed to describe multistage carcinogenesis accurately; however, it is hoped that the two-stage model will provide more accurate estimates of the cancer potency of chemicals that the multistage models currently in use by regulatory agencies.
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Key Terms

  • target cells
  • model requires
  • describe multistage
  • assist risk
  • biologic data

  • carcinogenesis accurately
  • questioned cram
  • appropriate target
  • current evidence
  • current procedures

  • extensive biologic
  • routine regulatory
  • time dependence
  • particular data
  • improve cancer

  • cancer risk
  • committee noted
  • cram chose
  • critical events
  • models currently

  • studying specific
  • carcinogenesis efforts
  • multistage carcinogenesis
  • risk estimates
  • phenomena thought

  • numerous assumptions
  • specific application
  • cancer potency
  • incomplete scientific
  • multistage models


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