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Drinking Water and Health, Volume 5 (1983) / Chapter Skim
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p-Dichlorobenzene
Pages 25-27

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From page 25...
... METAB OLISM The metabolism of p-dichlorobenzene was extensively studied in rats following repeated inhalation, oral, or subcutaneous doses (Hawkins et al., 1980~. After these exposures, residues detected by ]
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From page 26...
... These results indicated that the chemical enhanced metabolism of foreign compounds. Oral doses of p-dichlorobenzene given to female rats at doses of S0, 100, or 200 mg/kg daily for as long as 120 days produced significant dose-dependent increases in liver weight and liver porphyrin content, but they did not affect urinary excretion of porphyrins (Carlson, 1977~.
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From page 27...
... Because large quantities of this chemical are used, studies should be conducted to determine its reproductive effects, teratogenicity, and mutagenicity, especially from oral exposures. Acute and subchronic toxicity tests emphasizing potential hepatic toxic responses would also be desirable.
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Key Terms

  • drinking water
  • female rats
  • male rats
  • oral doses
  • material apparently

  • levels below
  • dose decreased
  • water committee
  • daily intake
  • intraperitoneal injection

  • acute effects
  • acid conjugate
  • additional data
  • repeated inhalation
  • occurred following

  • following occupational
  • days produced
  • chronic effects
  • safe drinking
  • committee calculated

  • occupational exposure
  • below limits
  • toxicity tests
  • single dose
  • anemia allegedly

  • increased severalfold
  • declined rapidly
  • hepatic toxic
  • minor urinary
  • liver weight


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