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Food Components to Enhance Performance An Evaluation of Potential Performance-Enhancing Food Components for Operational Rations (1994) / Chapter Skim
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22. Safety Concerns Regarding Supplemental Amino Acids: Results of a Study
Pages 455-460

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From page 455...
... National Academy Press 29 Safety Concerns Regarding Supplemental Amino Acids: Results of a Study Timothy J Maher' INTRODUCTION In the late summer and fall of 1989 there suddenly appeared a number of individuals who developed eosinophilia-myalgia syndrome (EMS)
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From page 456...
... to perform an extensive review of the scientific literature to determine the safety of amino acids used as dietary supplements (Federation of the American Societies for Experimental Biology, Life Sciences Research Office, 1992~. Not only was ~tryptophan use to be assessed for safety, but in addition, all the available amino acids were to be evaluated, since prolonged daily ingestion of large quantities of these compounds as dietary supplements is known to occur.
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From page 457...
... The potential for adverse effects associated with the ingestion of this amino acid in patients with this inherited metabolic abnormality are well documented (Lenke and Levy, 1980; Matalon et al., 1991~. Although manufacturers carefully avoid legal drug claim language on labels and advertising, many product labels and advertisments clearly suggested that such products provided pharmacological rather than nutritional benefit.
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From page 458...
... Such studies would include the determination of weight changes, food intake, neurological and behavioral changes, liver function, routine blood chemistry and hematological parameters, hormonal changes, and pharmacokinetic profiles following oral administration of the amino acid with and without food in both sexes. Multiple observation points would be used throughout the studies, and various doses would be employed.
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From page 459...
... 4:157-181. Federation of the American Societies for Experimental Biology, Life Sciences Research Office 1992 Safety of amino acids used as dietary supplements.
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From page 460...
... Austin, and F de la Cruz 1991 Maternal PKU collaborative study: The effect of nutrient intake on pregnancy outcome.
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