Technical Assessment of the Man-in-Simulant Test Program (1997) / Chapter Skim
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Appendix A: Body Region Hazard Analysis
Appendix A: Body Region Hazard Analysis
Pages 65-73
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APPENDICES page 65
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page 6Wblank
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CONCEPTS The practical goal of the BRHA is to convert the information derived from a multidimensional experimental testing plan into a concise measure of the relative protection value provided by a given candidate protective ensemble. The basic idea is to convert measurements of exposures at 20 different body locations into a single measure that accounts or the variability of both chemical exposure and relative sensitivity at each body location.
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It is eviclently well accepted that this is the normal function of the log of the exposure. Equation 1 summarizes this information in terms of s, the normal equivalent deviate, n, the natural Tog of the population response geometrical standard cleviation, M, the exposure, and M50, the exposure value at which half the population shows a physical reaction.
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In using Equation 9, the values of CETsoy are obtained from referenced toxicity studies involving human exposure to liquid VX (Sim, 19621. The application of these notions is slightly different for local anct systemic analysis.
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data for A percent and CETsoj represent the whole body exposure that, when uniformly appliect to the 20 different locations on an unprotected person, results in the reaction. The BRHA computes the actual challenge whole body exposure (or the whole body effective exposure ctiscussect in the body of the report)
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Systematic clevelopment would reveal the clepenclence of the mocle! parameters on the physical properties (e.g., ctiffusivities, adsorption anct absorption constants, viscosity, vapor pressures)
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. exposure in regl°n.1 specific exposure for each bocly region the mean response i that alone causes the exposure value at which half the population shows a physical reaction the natural log of the population response geometric mean standard deviation protected skin the local body region protection factor rating factor for protective clothing the normal equivalent deviate vj absorption velocity
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Army Chemical anct Biological Defense Commanct. Aberdeen Proving Ground, Mct., December 1996.
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