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Appendix B: American Society for Microbiology Recommendations
Pages 94-103

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From page 94...
... More basic research is needed to more clearly delineate mechanisms of antibiotic resistance and to identify new antimicrobial targets. Lastly, greater emphasis must be placed upon research related to rapid, reliable diagnostic tests and vaccines for prevention and control of infectious diseases.
From page 95...
... b. Establish a baseline of antimicrobial in vitro efficacy to which the following can be compared: earlier data from similar surveillance studies found in medical literature reviews, especially if these studies utilized comparable methodologies and surveillance techniques; subsequent surveillance data resulting from the establishment of a national surveillance system analyzed in a longitudinal manner; non-US.
From page 96...
... Various molecular typing and investigative procedures can lead to earlier understanding of developing resistance mechanisms and spread of epidemic clones. Allow for the future assessment of the encountered resistant pathogens' effect on patient outcomes, general community health, and the costs of health care delivery.
From page 97...
... and others as dictated by the needs of the surveillance oversight panel or requirements for spectrum validations as part of the interaction with industry colleagues (spectrum data for drug package inserts)
From page 98...
... . This would allow initial classification of participants by various parameters such as hospital size, services offered, formulary practices, antimicrobial use patterns, infection control practices, teaching status, etc.
From page 99...
... b. Where possible, initial screening should use the disk diffusion method (NCCLS M2-A5)
From page 100...
... b. Qualitative interpretations shall be applied objectively by computer programs based on current NCCLS tables.
From page 101...
... iii. Expanded list of antimicrobial agents and pathogens that will satisfy annual validation of drug package insert spectrum, YEARLY (winter quarter)
From page 102...
... This panel should include representatives from the principal federal agencies, members of the scientific community at large who are experts in antimicrobial resistance, specialists in infectious disease and in vitro antimicrobial testing in animals and humans, experienced personnel in multilaboratory surveillance, hospital/health care epidemiologists, computer and statistical analysts conversant with antimicrobial issues, and representatives of industry as dictated by consortium participation. The Antimicro
From page 103...
... ; (iv) availability of contemporary, localized data to federal and state agencies, enabling them to identify emerging resistances or pathogen frequencies and thus develop early interventions and selections of effective therapeutic regimens or prophylactic modalities; and (v)


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