Biographical Memoirs Volume 74 (1998) / Chapter Skim
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Stephen W. Kuffler
Stephen W. Kuffler
Pages 192-209
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fresh insights into mechanisms by which nerve cells generate electrical impulses, transfer information at synapses, en c! integrate signals.
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the free run of the estate, he greatly enjoyed horseback riding. At school Steve stucliec!
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Katz. Although Steve was to clevelop his own highly characteristic style of experimental research, Bernarc!
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By dissecting a single skeletal muscle fiber together with its nerve an immensely clifficult task Steve conic! analyze the events occurring at the synapse with greater precision than had hitherto been possible in intact muscles.
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Katz on crustacean muscles set the stage for later important studies on inhibition. SLOW MUSCLE FIBERS AND MUSCLE SPINDLES Steve's initial work in Chicago was on slowly contracting muscle fibers in the frog en c!
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just presented his new finclings at a meeting in Cambridge. Lord Adrian, the pioneer in our understanding of sensory signaling whom Steve greatly admired but hac!
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new insights into inhibitory mechanisms, again demonstrating efferent control by the central nervous system of information coming to it. An important pointer to the future was the study by Steve with Charles Ec~warcis of the effect of gammaaminobutyric acid (GABA)
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From this finding came the concept of spatial buffering whereby glial cells conic! control the extracellular environment of the neurons they surround.
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Steve took advantage of newly developed optical techniques (differential interference contrast) to observe living synapses between parasympathetic nerve cells in an icleal preparation (again!
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the presentation as well as the direct answers usually obviates!
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colleagues greatly exceeds the few names mentionec! above.
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From 1966 to 1974 he was the Robert Winthrop professor of neurobiology, en c! in ~ 974 he became John Franklin Enclers university professor.
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wisclom. A DETAILED, AFFECTIONATE, and authoritative account of Stephen Muffler s life and work has been provided by Sir Bernard Katz (Biographical Memoirs of Fellows of the Royal Society, vol.
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Function of medullated smallnerve fibers in mammalian ventral roots: efferent muscle spindle innervation.
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29:788-806. 1967 Neuroglial cells: physiological properties and a potassium mediated effect of neuronal activity on the glial membrane potential.
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76: 1501-1505. 1980 Slow synaptic responses in autonomic ganglia and the pursuit of a peptidergic transmitter.
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