Arsenic in Drinking Water (1999) / Chapter Skim
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1 Introduction
1 Introduction
Pages 10-15
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From page 10... ...
To meet those requirements, EPA's Office of Water requested that the National Research Council (NRC) review the arsenic toxicity data base and evaluate the scientific validity of EPA's 1988 risk assessment for arsenic in drinking water.
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Although EPA's Office of Water considers inorganic arsenic the form of concern in drinking water, the subcommittee decided to evaluate whether organic arsenic compounds in drinking water also contribute substantially to health risks. The report contains the subcommittee's review of data on the metabolism, toxicokinetics, and mechanism of action of arsenic in humans and animals and evaluation of the implications of those data for estimating exposure-response relationships below the range of detectable responses in human epidemiological studies.
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In 1989, EPA's Scientific Advisory Board (SAB) recommended that the agency revise its arsenic risk assessment to consider possible detoxification mechanisms that might substantially reduce cancer risks at low exposure levels (EPA 1989)
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Chapter 5 provides an overview of what is known about the disposition of arsenic in humans and nonhuman mammals and the implications of that information for estimating health effects associated with low-level exposures. In Chapter 6, the subcommittee evaluates various biomarkers as meaningful measures of the absorbed dose of inorganic arsenic.
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From page 14... ...
U.S. Environmental Protection Agency, Health Effects Research Laboratory, Research Triangle Park, N.C.
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From page 15... ...
U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, N.C.
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