Assessment of Future Scientific Needs for Live Variola Virus (1999) / Chapter Skim
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10 Understanding of the Biology of Variola Virus
10 Understanding of the Biology of Variola Virus
Pages 69-72
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From page 69... ...
The multiple mechanisms used by poxviruses to evade host immune responses, the unique proteins these viruses produce, and their interactions with the host are just beginning to be identified. As the database expands, questions about the interactions of variola virus with human cells and immune responses and about the functions of these disease-producing variola proteins will become more obvious and pressing.
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From page 70... ...
Infection of immune system cells could make it possible to assess direct effects on such cells, and incubation of human immune system cells with proteins secreted by infected cells could allow identification of potentially unique interactions between viral proteins and mediators of the antiviral immune response. These interactions could be used to identify important and potentially unique aspects of the human response to virus infections.
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From page 71... ...
· How does the virus damage host tissues and cells to-cause severe disease? Is this the direct result of virus replication in spleen, lymphoid, and bone marrow cells; virus production of mediators that damage even uninfected human cells; or induction of a harmful antiviral immune response?
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