Assessment of Future Scientific Needs for Live Variola Virus (1999) / Chapter Skim
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11 Research on the Expressed Protein Products of Variola
11 Research on the Expressed Protein Products of Variola
Pages 73-76
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From page 73... ...
In most cases studied to date, the viral proteins target unique regulatory or effecter components of the immune system. These host immune elements range from the cytokine network, to signal transduction pathways, to complement cascade, to cytotoxic lymphocyte killing mechanisms, to the innate apoptosis response to infections [5, 46, 50~.
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From page 74... ...
· Proteins that can control or favor the ability of a virus to grow in selected Some aspects of variola protein synthesis could be accomplished using only cloned genes, while others would require expression by the live virus. The following sections address first, the kinds of strategies that could be used for synthesis of variola virus proteins, and second, the potential usage of these expressed proteins for the study of human immunology and for the development of novel drugs to treat human immune-based diseases.
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From page 75... ...
This strategy would probably be the only way to reconstitute variola virus particles for authentic protein functional and structural studies aimed at the analysis of host cell receptors used by the virus or dissemination of the virus through the body. POTENTIAL UTILITY OF VARIOLA PROTEINS The two most important potential uses for variola proteins are as research tools to investigate the human immune system and as a source of new drugs to treat human diseases caused by aberrant immune functions.
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From page 76... ...
Finally, selected viral proteins from variola could perhaps stimulate immune tolerance pathways, which could lead to improved methods for blocking transplant rejection or achieving increased effectiveness of gene therapy vectors [601. Although the above uses remain hypothetical, the opportunity to investigate such avenues of research in the future will be dependent on the results of the World Health Assembly vote on the fixture of variola virus.
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