Assessment of Future Scientific Needs for Live Variola Virus (1999) / Chapter Skim
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Appendix A Glossary
Appendix A Glossary
Pages 93-98
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From page 93... ...
B cell, B lymphocyte: Bone marrow derived lymphocyte; originally differentiating in bone marrow, it can mature and multiply in the lymphoid organs when suitably stimulated. Base pair: Polynucleotide pairs with each purine base linked to its complementary pyrimidine base in the opposite DNA chain.
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From page 94... ...
Encephalitis: Acute disease of the central nervous system seen in persons convalescing from infectious disease, usually one of viral origin. Epithelial cell: Surface layer of cells closely bound to one another to form continuous sheets covering surfaces that may come into contact with foreign substances.
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From page 95... ...
MHC molecules: Major histocompatibility complex molecules that are found on the surface of almost all nucleated somatic cells; they control cellular immune reactions and are largely responsible for the rejection of organ transplants. Monocyte: A mononuclear phagocytic leukocyte.
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From page 96... ...
Polymerase chain reaction: A technique used to make numerous copies of a specific segment of DNA quickly and accurately; a three-step process carried out in repeated cycles that includes denaturation, or separation, of the two strands of the DNA molecule, each of which is a template on which a new strand is built in the second step, and to which the DNA polymerase adds nucleotides onto the annealed primers in the third step to double the DNA in each cycle. Prodrome: Premonitory symptom.
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From page 97... ...
SCID mouse: Severe combined imunodeficiency mouse, a mouse with a genetic inability to create diversity in its lymphocytes (no functional recombinase gene) , so that it lacks an effective immune response; reconstitution with human cells (SCID-hu)
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