Aromatic Amines An Assessment of the Biological and Environmental Effects (1981) / Chapter Skim
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p-Cresidine
p-Cresidine
Pages 274-287
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From page 274... ...
producer of E:cresidine is the Sherwin-Williams Company in St. Bernard, Ohio (Stanford Research Institute International, 1979~.
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From page 275... ...
J.; Direct Blue 126, produced by Harshaw Chemical Co., subsidiary of Gulf Oil Corp., Louisville Ky.; Direct Green 26, produced by Toms River Chemical Corp., Toms River, N J.; Direct Orange 34, produced by Cro~qpton ~ Knowles Corp., Fairlawn, N
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From page 276... ...
regulations for spares idine; however, the FDA regulations for Red No. 40 allow for the presence of up to 1% each of sulfonated subsidiary dyes used in its production (21 CER 741.
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From page 277... ...
Assays for Pur ity Analysis is accomplished by using a gas cbromatograph equipped with 1.5 m long column (0 .32 cm inner diameter) packed with 20% SE-30 on Chromosorb W AW DMCS (80-100 mesh)
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From page 278... ...
a midget bubbler charged with 10 ml of acetic anhydride followed by an activated carbon impinger and a membrane filter to protect the vacuum pump. Air samples are collected at a rate of approximately 1 1/minute for 1 to 2 hours.
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From page 279... ...
No deaths occurred in the male rats receiving 3% ~cresidine in any of the groups receiving the 1% diet or in the control group. Ch ron ic Tox ic i ty Ca rc inogen to ity .
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From page 280... ...
In addition, both high- and low-dose female mice had a significant incidence rate of hepatocellular carcinoma. Comparisons Of E~cresidine to other single-ring aromatic amines and to 2-FAA (N-2-fluorenylacetamide} for potency in producing urinary bladder tumors in rats and mice are shown in Figures 10-1 and 10-2.
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From page 281... ...
in Ct in C: o Ct en m _ _ 1 iL O _ — Z a: a 0 o IL ~ To 0 ~ ' 0 =- _ .
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From page 282... ...
In lo en o ~ - ~ J . r Figure 10-2 A comparison of the potency of single-ring aromatic amines and 2-FAA i n product ng b]
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From page 283... ...
Teratogen ic ity No data were available to evaluate the teratogenicity or reproduct ive tax ic i ty of p-c res id ine . CONCLUS IONS ED "C~NDATI AS Other than the cancer bioassay conducted by NCI, there is virtually no other biologic data on ~cresidine.
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From page 284... ...
Additional data are also needed on metabolism, metabolic activation, mutagenicity and genetic toxicity in path animal and human in vitro test systems.
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From page 285... ...
United States Production and Sales, 1977. USITC Publication 920.
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From page 286... ...
United States Production and Sales, 1978. USING Publication 1001.
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From page 287... ...
National Institute for Occupational Safety and Health. 1976 Reg i stry of Tox ic Ef f eats of Chemical Substances .
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