Committee on Military Nutrition Research Activity Report 1992-1994 (1994) / Chapter Skim
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D Letter Report: Committee on Military Nutrition Research Review of Three Research Proposals from the Pennington Biomedical Research Center, Submitted December 1992
D Letter Report: Committee on Military Nutrition Research Review of Three Research Proposals from the Pennington Biomedical Research Center, Submitted December 1992
Pages 77-96
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From page 77... ...
Appendix D Letter Report: Committee on Military Nutrition Research Review of Three Research Proposals from the Penrlirlgtor' Biomeclical Research Center Submitted December 1992
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17-92-V-2009 to the PBRC: "Military Nutrition Research: Six Tasks to Address Medical Factors Limiting Soldier Effectiveness." This grant to the PBRC was established to implement a program for which funds were specifically appropriated through the Department of Defense Appropriations Bill, 1988. The CMNR has on two previous occasions reviewed the work related to this program of research at the PBRC and submitted letter reports with recommendations.
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From page 80... ...
where they heard presentations and discussed the program orientations, goals, and preliminary research plans for three projects: basic neuroscience, clinical neuroscience, and menu modification. The role of the CMNR representatives at this meeting was as individuals participating in a discussion of scientific research directions.
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From page 81... ...
3: Nutritional Neurosciences Basic Science Laboratory Project Summary The purpose of project #3 is to investigate the mechanisms involved in REM (rapid eye movement, sleep phase) deprivation-induced cognitive dysfunction in the rat.
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This is of primary importance in order to plan protocols that build on prior relevant research. The committee voiced disappointment that no nutritional relevance was described in the basic project that is titled "nutritional neurosciences." It seems appropriate to expect that the basic studies laboratory should be testing nutritional hypotheses that relate to the clinical studies aspects of the same overall research program.
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From page 83... ...
Unless these ties become more evident, the project appears to be more appropriate for a standard individual proposal in a competitive grant arena rather than the present program. The research team should seek ongoing advice to strengthen the weak nutritional aspects of their experimental designs from nutritional scientists with expertise on dietary factors that alter behavior and neurotransmitter levels.
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From page 84... ...
General Comments The above comments regarding the issues of chronic versus acute dietary intervention and physiologic versus pharmacologic doses also apply to this program. Review of the written proposal and on-site discussion indicate that the scientific team has a thorough grasp of neurosciences literature on relevant concepts, methods, and measures.
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From page 85... ...
It is obvious that the investigators purposely were trying not to be too specific, but someone needs to decide what substances and or modifications, or both, will be tried. Specif c commer'Is, concerns and questions The addition of a nutrition research scientist trained in conducting human dietary studies to the project team would provide needed expertise in dietary design and subject management.
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From page 86... ...
11. In initially reading the proposal, one might assume that the pilot studies referenced in the first section would be in-house studies, with the larger community study planned as an outpatient study.
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The protocols should reflect the clinical objectives of the Army. Ongoing participation of a nutritional scientist familiar with human dietary studies will provide needed expertise in protocol development and subject management.
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Smoking and exercise habits of potential subjects should be considered as screening factors because of their effects on food intake and sleep behavior. Careful consideration should be given to the issue of whether task/test administration is varied from day-to-day or kept constant.
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From page 89... ...
Phase III will include a week in which modified menus will be served and a week of standard menus. Food acceptability will be assessed using computerized score sheets to be handed out at each meal during Phase III.
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Specific comments, concerns, or questions It is unclear whether modified menu items will be substituted in the standard menu in Phase II or modified menu days will be substituted. It is unclear whether the acceptability testing during Phase II will be only on the modified menu items (or days depending on the answer to #1)
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From page 91... ...
It is important to remember that highly preferred foods (such as desserts) are not necessarily eaten frequently, while moderately preferred foods, for example, bread, are eaten daily.
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From page 92... ...
The lead investigator has good expertise with data bases, but has little experience with large scale food services. The chef is dedicated but also an individual with little experience in very large scale food service with tight cost and ingredient constraints.
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From page 93... ...
The physical resources available at the PBRC are adequate to accomplish these three projects. While the overall staffing for the basic and clinical neurosciences projects appears well developed, the CMNR believes the projects require on going advice from nutritional scientists with expertise in dietary factors that alter behavior and neurotransmitter levels.
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From page 94... ...
Without appropriate planning, coordination, and staffing this project cannot make a significant impact on modifying Army menus in keeping with current healthful diet concepts. If improperly executed it would likely be a waste of time and resources.
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Prasad and Berthoud 11:00 - 12:00 noon Discussion of Menu Modification Project - Dr. Champagne 12:00 - 1:00 p.m.
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Marriott, Program Director PBRC Staff George Bray, Director Donna Ryan, U.S. Army Grant principal investigator Hans-Rudolf Berthoud Catherine Champagne Richard A
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