Monoclonal Antibody Production (1999) / Chapter Skim
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Introduction
Introduction
Pages 5-7
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From page 5... ...
Further processing of the mouse ascitic fluid and of the tissueculture supernatant might be required to obtain mAb with the required purity and concentration. The mouse ascites method is generally familiar, well understood, and widely available in many laboratories; but the mice require careful watching to minimize the pain or distress induced by excessive accumulation of fluid in the abdomen or by invasion of the viscera.
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From page 6... ...
Proper use of animals, including the avoidance or minimization of discomfort, distress, and pain when consistent with sound scientific practices, is imperative." The Guide for the Care and Use of Laboratory Animals (NRC 1996, page 10) specifically addresses excessive tumor burden in animals and states, "occasionally, protocols include procedures that have not been previously encountered or that have the potential to cause pain or distress that cannot be reliably controlled....
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From page 7... ...
The charge to the present committee excluded evaluation of steps needed to produce an antibody secreting cell line.
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