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(NAS Colloquium) The Neurobiology of Pain (1999) / Chapter Skim
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The Neurobiology of Pain
Pages 7627-7630

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From page 7627...
... The molecular identity of nociceptors, their stimulus transduction processes, and the ion channels involved in the generation, modulation, and propagation of action potentials along the axons in which these nociceptors are present are being vigorously pursued. Similarly, tremendous progress has occurred in the identification of the receptors, transmitters, second messenger systems, transcription factors, and signaling molecules underlying the neural plasticity observed in the spinal cord and brain stem after tissue or nerve injury.
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From page 7628...
... Amy MacDermott started the session by describing results from recent experiments performed in her laboratory designed to investigate the role of presynaptic non-N-methyl-D-aspartate receptors at the first synapse in the nociceptive pathway. Utilizing a dorsal root ganglion neuron/dorsal horn neuron co-culture, MacDermott and her colleagues obtained evidence indicating dorsal root ganglion neurons express functional or-amino-3-hydroxy-5methyl-4-isoxazolepropionic acid and kainate receptors.
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From page 7629...
... brought trophic factors back to center stage with his summary of a growing body of data implicating a critical role for brain derived neurotrophic factor in the altered nociceptive processing observed in the presence of inflammation. Brain derived neurotrophic factor appears to function as a neurotransmitter/neuromodulator in the dorsal horn of the spinal cord, where it is released from the central terminals of small-caliber afferents and increases the excitability of dorsal horn neurons.
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From page 7630...
... 7630 Colloquium Paper: Dubner and Gold 13. Urban, M
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Key Terms

  • nerve injury
  • dorsal horn
  • pain research
  • horn neurons
  • experiments performed

  • evidence indicating
  • sensory neurons
  • protein kinase
  • sodium channel
  • tissue injury

  • major advances
  • root ganglion
  • brain derived
  • dorsal column
  • ventral medulla

  • dorsal root
  • neurotrophic factor
  • central sensitization
  • rostral ventral
  • derived neurotrophic

  • brain stem
  • provided evidence
  • exciting series
  • recent experiments
  • neural plasticity

  • hyperalgesia associated
  • stimulus transduction
  • central nervous
  • functional mri
  • ion channel


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