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(NAS Colloquium) The Neurobiology of Pain (1999) / Chapter Skim
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Calcium Regulation of a Slow Post-spike Hyperpolarization in Vagal Afferent Neurons
Pages 7650-7657

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From page 7650...
... Such an anatomical relation might be particularly beneficial for modulation of spike-frequency adaptation in vagal afferent neurons. Activation and sensitization of primary afferent nerve fibers during allergic inflammation are orchestrated by inflammatory mediators released from various cells, including tissue mast cells.
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From page 7651...
... All data points were recorded from a single acutely dissociated adult rabbit nodose neuron at room temperature. Resting potential and membrane input resistance were -55 mV and 53 MQ, respectively.
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From page 7652...
... blocks the AHPs~ow within 5 min without changing the resting membrane potential or membrane input resistance. APs were evoked by transmembrane depolarizing current pulses (4 nA, 1.5 ms, 10 Hz)
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From page 7653...
... Comparison of IK-SIOW and IK-me~ium Peak Holding potential, mV conductance, Current nS n IK-SIOW 27.9 + 6.5 14 -55.4 + 2.7 IK medium 53.2 + 16.5 6 -20 + 3.7 IK-S1OW and IK-medium are outward currents elicited by iontophoretic injection Ca2+ into acutely isolated nodose neurons of the rabbit. The peak conductance is the largest conductance elicited, independent of membrane potential.
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From page 7654...
... O on the caffeine responses prevents a meaningful interpretation of the effect of [Ca2+] O on the releasable content of the CICR pool.
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From page 7655...
... (A) Inward calcium currents recorded in isolated nodose neurons evoked by a prerecorded AP waveform from a holding potential of - 60 mV.
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From page 7656...
... The nearly spherical morphology and large size of acutely isolated adult nodose neurons provide a favorable preparation to determine the nature of second messengers required to activate and sustain the AHPs~ow. In conclusion, a subset of vagal primary afferent neurons possess a slowly developing and long-lasting spike afterhyperpolarization, the AHPs~ow' that can profoundly affect the discharge frequency of these visceral afferent neurons.
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From page 7657...
... Colloquium Paper: Cordoba-Rodriguez et al.
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Key Terms

  • cicr pool
  • afferent neurons
  • vagal afferent
  • locke solution
  • type channels

  • plasma membrane
  • endoplasmic reticulum
  • eight aps
  • acutely isolated
  • inflammatory mediators

  • transients evoked
  • resting membrane
  • membrane potential
  • calcium channels
  • primary afferent

  • nodose neuron
  • solution containing
  • delayed onset
  • depolarizing current
  • vagal primary

  • current pulses
  • rabbit nodose
  • single aps
  • potassium channels
  • peak amplitude

  • decay time
  • holding potential
  • triggers cicr
  • channels triggers
  • cicr pools


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