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(NAS Colloquium) The Neurobiology of Pain (1999) / Chapter Skim
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Neutrophins and Hyperalgesia
Pages 7693-7696

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From page 7693...
... Because brain-derived neurotrophic factor is up-regulated in trkA positive cells after inflammatory injury and is transported anterogradely, we consider it to be a potentially important peripheral component involved in neurotrophin-induced hyperalgesia. It is now well established that, in late embryonic life, sensory neurons depend on the availability of peripherally derived factors for survival; this dependence is referred to as the neurotrophic hypothesis (1~.
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From page 7694...
... These experiments established that NGF changes the threshold of nociceptive afferents and that mast cells are involved. They also confirmed a peripheral locus for the sensitizing action of NGF.
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From page 7695...
... However, if exogenous NGF degranulates mast cells, and these, in turn, release NGF, then the resulting positive feedback cycle would amplify the amount of NGF activating the sensory ending. In effect, this hypothesis suggests that exogenous NGF acts as a trigger that liberates NGF from mast cells.
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From page 7696...
... (1993) Trends Neurosci.
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Key Terms

  • noxious heat
  • sensory neurons
  • exogenous ngf
  • drg cells
  • afferent fibers

  • nociceptive afferents
  • receptive field
  • trka receptors
  • root ganglion
  • dorsal root

  • neurotrophic factor
  • peripheral sensitization
  • capsaicin receptor
  • growth factor
  • nerve growth

  • inflammatory injury
  • thermal hyperalgesia
  • applied directly
  • prior degranulation
  • capsaicin responses

  • nociceptive neurons
  • trkc receptors
  • nociceptive afferent
  • perforated patch
  • express trka

  • directly sensitize
  • direct effect
  • ngf acts
  • neurotrophin family
  • patch clamp


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