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(NAS Colloquium) The Neurobiology of Pain (1999) / Chapter Skim
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Distinct Neurochemical Features of Acute and Persistent Pain
Pages 7739-7743

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From page 7739...
... receptor, which is targeted by SP-containing afferents, are projection neurons (10~. By contrast, the nonpeptide group of small-diameter afferents targets a region of the superficial dorsal horn that exclusively contains interneurons, namely the inner part of lamina II.
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From page 7740...
... Furthermore, although the NK-1 receptor mutants showed reduced second-phase formalin test responses, the PPT-A mutant mice had only reduced first-phase behavior. Although there is disagreement concerning the extent to which central sensitization contributes to secondphase pain in the formalin test (27, 28)
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From page 7741...
... , which are found throughout the superficial dorsal horn as well as more ventrally. The presence of PKC^y in the inner part of lamina II raises the possibility that the phenotype of the deletion mutant is, at least in part, related to loss of the consequences of activation of the nonpeptide population of primary afferents that target this region.
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From page 7742...
... Taken together, these results suggest either that the signal that is sent from the site of nerve injury to the dorsal root ganglia and spinal cord is not transmitted properly in the PKC^y-null mice, or that the response to the signal by dorsal horn neurons is altered. We favor the latter hypothesis and suggest that it is a signal in the nonpeptide population of small-diameter nociceptors that is not processed normally by the PKCy interneurons of the inner part of lamina II.
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From page 7743...
... Colloquium Paper: Basbaum 29.
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Key Terms

  • spinal cord
  • mutant mice
  • horn neurons
  • superficial dorsal
  • persistent pain

  • nociceptive processing
  • nerve injury
  • primary afferent
  • noxious stimuli
  • acute pain

  • dorsal root
  • sciatic nerve
  • fos expression
  • nerve section
  • nonpeptide population

  • nonnoxious stimuli
  • partial sciatic
  • root ganglia
  • induces fos
  • primary afferents

  • capsaicin receptor
  • persistent injury
  • gene products
  • protein kinase
  • acute noxious

  • inner lamina
  • pain conditions
  • preliminary studies
  • studies using
  • formalin test


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