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(NAS Colloquium) The Neurobiology of Pain (1999) / Chapter Skim
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The u Opiate Receptor as a Candidate Gene for Pain: Polymorphisms, Variations in Expression, Nociception, and Opiate Responses
Pages 7752-7756

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
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From page 7752...
... Strain-comparison studies have identified both reduced antinociceptive responses to morphine and lower levels of ,uOR expression in some mouse strains, although these are correlations that do not directly document causal relationships between differences in ,uOR expression levels and observed differences in morphine responses (8-10~. Differences in morphine responses between DBA and C57 mice as well as the BxD recombinant inbred strains derived from these parental lines can be mapped by using quantitative trait locus approaches (11-14~.
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From page 7753...
... 14. Studies of rapid amplification of cDNA 5' ends have suggested to other workers that two nearby regions provide the sites at which primer extension products terminate, which are thus potential transcriptional initiation sites (-793 and -268 bp from the translational start site; refs.
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From page 7754...
... and more 5' sites for transcriptional initiation or highly conserved regulatory regions, searches in more 5' genomic regions also make sense. Workers are currently undertaking approaches consisting of cloning additional 5' genomic sequence, searching for simple sequence repeat and single nucleotide polymorphisms, characterizing the individual differences in these polymorphic sites, and applying these polymorphisms to seek correlations with ,uOR expression levels and nociceptive responses.
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From page 7755...
... (1985) Brain Res.
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Key Terms

  • genomic sequences
  • transcriptional initiation
  • nociceptive thresholds
  • recombinant inbred
  • drug responses

  • nucleotide polymorphisms
  • start site
  • opiate drug
  • morphine responses
  • single nucleotide

  • initiation sites
  • expression levels
  • translational start
  • simple sequence
  • intramural research

  • quantitative trait
  • genetic bases
  • nociceptive responses
  • bxd recombinant
  • trait locus

  • sequence repeat
  • extension products
  • primer extension
  • human individuals
  • regulatory regions

  • provide powerful
  • lower nociceptive
  • mouse strains
  • opiate receptor
  • opiate drugs


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