Toxicity of Military Smokes and Obscurants Volume 3 (1999) / Chapter Skim
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Appendix C: Solvent Yellow 33
Appendix C: Solvent Yellow 33
Pages 58-70
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From page 58... ...
with a geometric standard deviation of 1.7. At the end of exposure, greater than 90% of the radioactivity remaining in the lungs was unmetabolized solvent yellow 33.
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From page 59... ...
Analysis of the bile revealed no intact i4C-QID, but more than 10 metabolites were detected. In summary, the results of pharmacokinetic studies of solvent yellow 33 administered to animals by inhalation, by injection, or in feed suggest that, after inhalation by humans, solvent yellow 33 will be rapidly absorbed from the respiratory tract, and extensively metabolized, with the metabolites excreted in the bile and eliminated in the feces.
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From page 60... ...
Jordan (1981) describes contact dermatitis due to solvent yellow 33 in I: of 149 volunteers who developed a sensitization reaction when tested with solvent yellow 33 concentrations of 16.4 ppm in a modified Draize test.
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From page 62... ...
. Mild respirator~r-function changes consisting of reduced elastic recoil, increased resting lung volumes, and reduced respiratory flow rates were found at the highest concentration.
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63 Cat CO > o cn ._ o in ._ cn .~ ._ o o cn Cal m a, a' a' to in Cal U)
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From page 65... ...
Histological evaluation of selected skin sites demonstrated a cellular inflammatory response consistent with delayed-type hypersensitivity. On the basis of the frequency and severity of the reaction scores, the authors concluded that solvent yellow 33 could be considered a fairly potent sensitizer, with a 50-,ug dose considered a strong sensitizer.
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From page 66... ...
.. Solvent yellow 33 has been tested for mutagenicity in a variety of assays including mouse micronucleus, L5178-Y mouse lymphoma, SaZmoneZZa reversion, and sister chromatic exchange using Chinese hamster ovary cells and the C57Bl/6 mouse.
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From page 67... ...
67 Cal 3 > o cn .~ a)
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From page 68... ...
However, because the rate of reversion in strain TAl04 was less than double that in controls, the subcommittee concluded that the results were only weakly positive in this strain. Solvent yellow 33 produced positive results in the mouse lymphoma assay with and without metabolic activation (Moore et al.
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From page 69... ...
Final Report Phase II Studies: Range Finding and Toxicokinetics Studies of Inhaled Dye Aerosols. Final Report AD A163267.
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From page 70... ...
11 in guinea pigs. Contact Dermatitis 9~53:367-371.
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