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Variation and Evolution in Plants and Microorganisms Toward a New Synthesis 50 Years After Stebbins (2000) / Chapter Skim
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Part II: Viral and Bacterial Models
Pages 59-60

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From page 59...
... Moya et al. conclude with an examination of the advantages and disadvantages of traditional population genetics theory for the description of viral evolution vis-a-vis the quasi-species concept, which proposes that the target of natural selection is not a single genotype but rather a cloud of mutants distributed around a most frequent one, the "master sequence." Robin M
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From page 60...
... sampling bias, induced by the preference of investigators for sequencing antigenetically dissimilar strains for the purpose of identifying new variants that might call for updating the vaccine which seems to be the main factor accounting for the replacement excess in terminal branches. The authors point out that the matter is of consequence in vaccine development, and that host-mediated mutations should be removed before making decisions about influenza evolution.
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Key Terms

  • sampling bias
  • population genetics
  • terminal branches
  • rna encoding
  • genetic elements

  • natural selection
  • substitutions observed
  • directly onto
  • fairly directly
  • main factor

  • five proteins
  • passage history
  • infectiously transmitted
  • single genotype
  • antigenetically dissimilar

  • map fairly
  • mutants distributed
  • traditional population
  • transmitted genetic
  • authors grow

  • dissimilar strains
  • factor accounting
  • genetics theory
  • viral evolution
  • encoding five

  • control clone
  • phylogenetic reconstruction
  • sequencing antigenetically
  • variable demographic
  • viral clones


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