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Submarine Exposure Guidance Levels for Selected Hydrofluorocarbons HFC-236fa, HFC-23,and HFC-404a (2000) / Chapter Skim
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Pages 18-19

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From page 18...
... (1997) reported on a subchronic toxicity study in which groups of five male and five female rats were exposed (nose only)
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From page 19...
... Rats exposed at 5,000 or 20,000 ppm exhibited normal alerting responses. On study day 1, most rats in the 50,000-ppm group exhibited a diminished response.
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Key Terms

  • male rats
  • clinical signs
  • toxicity study
  • female rats
  • body weights

  • alerting response
  • rats exposed
  • inhalation exposure
  • body weight
  • alerting responses

  • inhalation study
  • ppm exhibited
  • rats died
  • normal alerting
  • peroxisome proliferation

  • transient decrements
  • diminished alerting
  • subchronic exposure
  • five female
  • test days

  • consecutive days
  • five male
  • target concentration


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