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Submarine Exposure Guidance Levels for Selected Hydrofluorocarbons HFC-236fa, HFC-23,and HFC-404a (2000) / Chapter Skim
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... A developmental toxicity study in rats reported reduced weight gain and decrements in alerting response in pregnant animals exposed at 20,000 ppm. That is the same concentration as the NOAEL in the 14-week toxicity study used to calculate the 24-hr EEGL and the 90-day CEGL.
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Key Terms

  • maternal toxicity
  • toxicity study
  • developmental toxicity
  • alerting response
  • interspecies variability

  • female crew
  • day cegl


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