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Submarine Exposure Guidance Levels for Selected Hydrofluorocarbons HFC-236fa, HFC-23,and HFC-404a (2000) / Chapter Skim
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Pages 66-70

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From page 66...
... . , ~~ A statistically significant increase in subacute and chronic laryngitis occurred in female rats only in the 50,000-ppm group.
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From page 67...
... The subcommittee used the new studies to reevaluate the exposure guidance levels proposer! by the NRC in 1996 and those currently user!
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From page 69...
... 69 ~ In ~ ~ ~ n; ~ ~ ~ o~ _ o ~ 0 ~ 0 ~ ~ ~ v~ c~ E c2 a~ ~, x 0' x ~ x ~ ,, ¢7, E b4 ' oo b4 ~ Y ~ _ ,, ~D In o L~ o o o oo o o o o o o o o o o o o a a ~ ~ O O ~ =- Oo ~ =- ~ ~ ~ ~ z z z z ~ ~ z ~ ~ z ~ z z z z 0 0 0 0 0 0 0 0 0 0 0 0 0 O O ~ O O O O O O O O O O O O ° 0 ~ 0 0 O- 0 0 0 0 0 0 0 0 0 O ~ ~ o O O O O ~ O ~ O 0 0 0 ~ ~ ~ oo ~ ~ In ~ ~ ~ ~ ~ In In ~ ~i ~ ~ ~ ~ ~ ~o ~ ~ ~ ~ ~ .~ ~ ~ ~ ~ ~= c: ~ ~ · - x ~ .
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From page 70...
... 70 Lit <: ~ O Q Lo O ~ Z - .
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Key Terms

  • male rats
  • significant increase
  • guidance levels
  • exposure guidance
  • toxicity study

  • female rats
  • interspecies variability
  • clinical observations
  • exposure level
  • subsequently published

  • guidance level
  • female crew
  • submariner population
  • intraspecies variability
  • tissue pathology

  • concentration safety
  • irwin screen
  • day cegl


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