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Submarine Exposure Guidance Levels for Selected Hydrofluorocarbons HFC-236fa, HFC-23,and HFC-404a (2000) / Chapter Skim
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Pages 71-72

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From page 71...
... However, slight maternal toxicity in the absence of other adverse effects might not be a suitable indicator for health-hazard evaluation in Navy vessels with no female crew members. Several general toxicity stuciies ranging from 2 to 13 weeks cluration were conducted on the three components.
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From page 72...
... to integrate available interaction data (Mumtaz and Durkin 1992~. Recent experimental studies have shown that the WOE method is useful in assessing the toxicity of low-concentration exposures to chemical mixtures (Mumtaz et al.
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Key Terms

  • maternal toxicity
  • male rats
  • cardiac sensitization
  • significant increase
  • toxicity study

  • chemical mixtures
  • adverse clinical
  • fetal toxicity
  • interspecies variability
  • exposure level

  • slight maternal
  • available interaction
  • interaction data
  • individual components
  • reproductive toxicity

  • subchronic exposure
  • results indicate
  • female crew
  • woe method
  • little uptake

  • integrate available
  • interactions leading
  • biological significance
  • multiple chemicals
  • acute exposure


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