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A Healthy NIH Intramural Program Structural Change or Administrative Remedies? Report of a Study (1988) / Chapter Skim
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Appendix C SUMMARY OF ACHIEVEMENTS OF NIH INTRAMURAL PROGRAMS
Pages 148-155

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From page 148...
... The third category, basic science, outlines numerous contributions of the NIH intramural program to an extended understanding of normal and abnormal physiological and cell biological processes. Finally, the fourth category lists some special programs or studies that do not easily fit into the other categories.
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From page 149...
... Please use the print version of this publication as the authoritative version for attribution. -- Development of new vaccines against important bacterial infections of infants and children, including Hemophilus influenzae type B, pertussis, and typhoid.
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From page 150...
... Please use the print version of this publication as the authoritative version for attribution. -- Discovery of the human immunodeficiency virus (HIV)
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From page 151...
... -- Identification of genes that code for cellular proteins involved in the and some typographic errors may have been accidentally inserted. Please use the print version of this publication as the authoritative version for attribution.
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From page 152...
... Please use the print version of this publication as the authoritative version for attribution. -- Identification of different patterns of gene expression during the various stages of blood cell maturation and differentiation.
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From page 153...
... -- Demonstration that biological molecules such as cyclic AMP, glucocorticoids, nerve growth factor, and activators of protein kinase C can act together to regulate the genes that code for enkephalin and neuropeptide Y, substances found to function in the brain and many other tissues. -- Discovery of the mechanism for pertussis toxin effects on signal transduction across cell membranes in which a toxin enzyme structurally modifies a membrane protein required for transmembrane signalling.
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From page 154...
... -- Gene transfer and expression in intact animals using retroviral vectors. -- Achievement of successful "gene therapy" of a defective cell in tissue culture by microinjection of a cloned normal gene.
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From page 155...
... -- Extensive program of evaluation of prosthetic heart valves and the mechanisms of their failure. -- Development of useful equipment and technology including: closed circuit blood centrifuge, disposable membrane artificial lung, countercurrent chromatography, global analysis for time-resolved fluorescence spectroscopy, the porous bottomed culture dish, a purification method to standardize hemoglobin in the development of a blood substitute, and a new stopped-flow calorimeter for studies of drug binding to DNA.
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Key Terms

  • accidentally inserted
  • typographic errors
  • muscle contraction
  • nih intramural
  • intramural program

  • direct clinical
  • growth factor
  • clinical practice
  • kidney function
  • protein kinase

  • immunodeficiency virus
  • special programs
  • mechanisms involved
  • growth factors
  • cause interstitial

  • human globin
  • cell maturation
  • human diseases
  • brain regions
  • cell regulatory

  • normal gene
  • myelin protein
  • transforming growth
  • brain cells
  • nationwide cancer

  • discrete brain
  • clinical applications
  • elucidate basic
  • cause regressions
  • human immunodeficiency


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