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Review of NASA's Biomedical Research Program (2000) / Chapter Skim
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6 Endocrinology and Nutrition
Pages 40-45

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From page 40...
... Quite apart from the intrinsic scientific interest of the underlying mechanisms, understanding the effects of spaceflight on the endocrine system is essential for the rational development of countermeasures. The principal spaceflight responses that have a significant endocrine involvement are fluid shifts; perturbation of circadian rhythms; losses of red cell mass, bone, and muscle; and maintenance of energy balance.
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From page 41...
... For the most part, endocrine measurements are secondary objectives. The endocrine components of currently funded studies are directed toward elucidating underlying mechanisms, as recommended in the Strategy report.
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From page 42...
... The endocrine component of the current NRA and NSBRI research programs is small. This is consistent with the Strategy report conclusions and appropriate given the lack of flight opportunities.
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From page 43...
... Balance of Ground and Flight Investigations The small research program in endocrinology is predominantly ground based because of a lack of flight opportunities. Two of the three strategy recommendations require flight experiments, namely, determination of the in-flight human endocrine profile and further refinement of ground-based models.
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From page 44...
... DEVELOPMENT AND VALIDATION OF COUNTERMEASURES One of the bed rest countermeasure studies, the use of alendronate to reduce bone calcium loss, involves a series of measurements to evaluate any endocrine perturbations induced by the drug. The study involves a close interaction between university investigators (NRA funded)
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From page 45...
... SUPPORT OF ADVANCED TECHNOLOGIES For the most part, new methodologies particularly sensitive micromethods are not being used in individual research programs. At the First Biennial Life Sciences Investigators' Workshop, NASA (Ames)
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Key Terms

  • flight opportunities
  • circadian rhythm
  • hormone profile
  • endocrine measurements
  • stone formation

  • human hormone
  • renal stone
  • endocrine involvement
  • energy balance
  • circadian rhythms

  • human endocrine
  • report identified
  • endocrine component
  • endocrine profile
  • significant endocrine

  • endocrine aspects
  • flight experiments
  • flight data
  • advanced technologies
  • gastrointestinal function

  • rhythm studies
  • body composition
  • significant nutrition
  • endocrine components
  • current lack

  • nra solicitation
  • rhythm dysfunction
  • neurolab projects
  • currently funded
  • require flight


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