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Possible Long-Term Health Effects of Short-Term Exposure To Chemical Agents, Volume 3 Final Report: Current Health Status of Test Subjects (1985) / Chapter Skim
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Discussion
Pages 25-30

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From page 25...
... There were two main reasons for this procedure: the Edgewood studies were conducted to determine immediate behavioral effects that might be important in a military situation, and the later exposure of controls to experimental chemicals enabled the experimenter to make multiple use of each volunteer. A need for evaluating long-term health effects was not foreseen.
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From page 26...
... Hence, the objective of this study was to detect major, long-term health effects of the exposures to chemicals. Additional information on admissions to Army and VA hospitals was available.
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From page 27...
... ANTICHOLINESTERASE CHEMICALS The primary health concern regarding subjects tested with anticholinesterases\was that long-term health effects might occur in the form of subtle changes in EEG, sleep pattern, and behavior -- such as increased irritability, inability to concentrate and depression-that could persist for more than a year (Appendix A)
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From page 28...
... The neoplasms occurred at various sites, and no consistent pattern was seen. Current animal studies show that this pharmacologic class is unlikely to have induced malignancies among the Edgewood subjects; that conclusion is based on a review of NCI-sponsored lifetime studies of animal bioassay for carcinogenesis at maximal tolerated doses of ten anticholinesterase organophosphate pesticides.
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From page 29...
... The data supplied by the soldiers in response to the questionnaire and the patterns of admissions of these soldiers to military hospitals did not contradict these conclusions with regard to specific health effects. Of particular interest were the 86 soldiers who were exposed to some form of Sernyl, a purified form of phencyclidine.
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From page 30...
... The primary short-term health effects of the dibenzopyrans were moderate to marked and included prolonged orthostatic hypotension. However, there was no indication from the responses on the questionnaire that the current health of exposed subjects was affected.
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Key Terms

  • health status
  • mental disorders
  • hospital admissions
  • male children
  • health concern

  • test subjects
  • malignant neoplasms
  • oct subjects
  • primary health
  • edgewood studies

  • subjects tested
  • expected values
  • soldiers exposed
  • mustard gas
  • excess malignancies

  • subtle changes
  • apparent difference
  • test population
  • current age
  • chemical testing

  • subjects exposed
  • major health
  • pollution containing
  • literature reporting
  • necrologic disorders

  • fertility rates
  • organophosphate pesticides
  • behavioral effects
  • prolonged orthostatic
  • ten anticholinesterase


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