Possible Long-Term Health Effects of Short-Term Exposure To Chemical Agents, Volume 3 Final Report: Current Health Status of Test Subjects (1985) / Chapter Skim
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Pages 33-62
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From page 33... ...
(Some subjects had multiple tests.) b Excludes 100 volunteers whose years of birth were missing and who were excluded from mortality analysis.
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TABLE 2 Median Years in Which Categories of Chemicals were Administered Category Anticholinesterases Anticholinergics Cbolinesterase Deactivators Sernyl Irritants Cannabinoids [SD derivatives Approved drugs Year 1962 1968 1968 1959 1967 1965 1959 1971 Innocuous chemicals and controls 1971 -34
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From page 35... ...
Exposed Respondents and Magnitude of Risk Increase Due to Exposure 0.005 0.010 Probability of Detecting Increased Risk if Risk of Outcome Among 1,058 NCT Subjects Is 0.500 . 0.050 0.100 1,000 exposed: 0.001 0.090 0.077 0.062 0.058 0.055 0.010 0.770 0.545 0.258 0.183 0.117 0.100 1.000 1.000 1.000 1.000 0.998 500 exposed: 0.001 0.088 0.075 0.060 0.057 0.054 0.010 0.647 0.488 0.211 0.153 0.101 0.100 1.000 1.000 1.000 1.000 0.981 100 exposed: 0.001 0.080 0.068 0.056 0.054 0.052 0.010 0.395 0.289 0.130 0.100 0.073 0.100 1.000 0.999 0.953 0.870 0.606 -35
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From page 36... ...
Exposed Respondents and Magnitude of Risk Increase Due to Exposure 1,000 exposed (2,027 OCT respondents) : 0.001 0.010 0.100 500 exposed (2,527 OCT respondents)
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1,894 123 1,771 93.5 1,353 76.4 1,058 59.7 78.2 Totalb 6,720 325 6,395 95.2 4,996 78.1 4,085 63.9 81.8 a Includes total number of volunteers tested with given chemical group, regardless of whether they were tested with chemicals from other chemical groups.
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From page 38... ...
% Anticholinesterases 1,301 37 2.8 Anticholinergics 1,642 36 2.2 Cholinesterase Deactivators 661 16 2.4 Sernyl 66 3 4.5 Irritants-vesicants 1,872 53 2.8 Cannabinoids 219 8 3.7 LSD 406 18 4.4 None (NCT) 1,584 54 3 4 Totalb 5,682 171 3.0 a Includes total number of volunteers tested with given chemical group, regardless of whether they were tested with chemicals from other chemical groups.
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From page 39... ...
TABLE 9 Volunteers Who Were Exposed to Anticholinesterases and Requested Results of Studya (A Sample of the Computer Tables Used in the Preliminary Screening of Data) Volunteers Exposed to Anticholinesterases Age in 1984, Years Renuested A ALN A AND TTL A CNTRL OTHER NOT A TOTAL Under 35 Yes No.
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From page 40... ...
TABLE 9 (continued) Age in 1984, Years Requested A ALN A AND TTL A CNTRL OTHER NOT A TOTAL 55 and over Yes No.
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From page 41... ...
Questionnaire responses: Self-rating of health Marital history: Current marital status Times married Present living arrangements Employment history: Number of jobs reported Current~occupation Liveborn children: Number of children Sex of children Birth defects Current survival status of children Health problems due to toxic exposure Smoking history: Ever smoked Current smoking Use of alcoholic beverages: Daily use History of abuse Use of controlled substances Medical problems: Illness, preceding 5 years Hospitalized, preceding 5 years Confined to bed, preceding month Impairments: Work, chores Personal care a ICD-8 = Eighth Revision International Classification of Diseases.
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From page 42... ...
TABLE 11 Admissions to Army Hospitals and Admission Rates Per 1,000 Person-Years of Observation, by Years Since Testing (Volunteers Exposed to Only One Chemical Group) Years Since Testing Chemical Group 0-4 5-9 10-14 15-19 20+ Total No.
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From page 43... ...
TABLE 12 Admissions to Army Hospitals and Admission Rates Per 1,000 Person-Years of Observation, by Years Since Testing (Volunteers Exposed to More than One Chemical Group) Years Since Testing Chemical Group 0-4 5-9 10-14 15-19 20+ Total No.
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From page 44... ...
TABLE 13 Volunteers Admitted to Army Hospitals and Percent of Volunteers Still in Service Who Were Hospitalized, by Years Since Testing (Volunteers Exposed to Only One Chemical Group) Years Since Testing Chemical Group 0-4 5-9 10-14 15-19 20-24 25+ No.
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From page 45... ...
TABLE 14 Volunteers Admitted to Army Hospitals and Percent of Volunteers Still in Service Who Were Hospitalized, by Years Since Testing (Volunteers Exposed to More than One Chemical Group) Years Since Testing Chemical Group 0-4 5-9 10-14 15-19 20-24 25+ No.
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From page 46... ...
TABLE 15 Admissions to VA Hospitals and Admission Rates Per 1,000 Person-Years of Observation, by Years Since Separation from Service (Volunteers Exposed to Only One Chemical Group) Years Since Separation Chemical Group 0-4 5-9 10-14 15-19 20-29 Total No.
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From page 47... ...
TABLE 16 Admissions to VA Hospitals and Admission Rates Per 1,000 Person-Years of Observation, by Years Since Separation from Service (Volunteers Exposed to More Than One Chemical Group) Years Since Separation Chemical Group 0-4 5-9 10-14 15-19 20+ Total No.
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From page 48... ...
NCT ExP.b OCT Ex~.a Obs. NCT ExP.b Anticholinesterases 1.0 2 2.5 1.0 4 0.0 Other chemical tests -- 2 5.1 -- 2 0.0 Anticholinergics 2.4 0 2.9 1.8 3 0.0 Other chemical tests -- 4 4.8 -- 3 0.0 Cholinesterase Deactivators 0.7 0 1.2 0.7 - 2 0.0 Other chemical tests -- 4 6.5 -- 4 0.0 Sernyl 0.1 0 0.1 0.1 0 0.0 Other chemical tests -- 4 7.5 -- 6 0.0 Irritants-vesicants 1.6 2 3.4 3.2 2 0.0 Other chemical tests -- 2 4.3 -- 4 0.0 Cannabinoids 0.2 0 0.4 0.3 0 0.0 Other chemical tests -- 4 7.2 -- 6 0.0 LSD 0.4 1 0.9 0.7 1 0.0 Other chemical tests -- 3 6.7 -- 5 0.0 None (NCT)
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From page 49... ...
. b Based on no-chemical-test group experience: number of volunteers tested with this chemical group times proportion of volunteers with first admissions among those not tested with any chemical group (NCT)
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From page 50... ...
NCT Exp.b OCT Exp.a Obs. ACT Exp.b Anticholinesterases 11.7 11 6.7 4.9 3 2.5 Other chemical tests -- 24 13.7 -- 10 5.1 Anticholinergics 16.7 7 7.6 3.6 7 2.9 Other chemical tests -- 28 12.8 -- 6 4.8 Cholinesterase Deactivators 5.5 5 3.2 1.8 3 1.2 Other chemical tests -- 30 17.2 -- 10 6.5 Sernyl 0.6 0 0.4 0.2 0 0.1 Other chemical tests -- 35 20.0 -- 13 7.5 Irritants-vesicants 19.0 11 9.0 7.1 4 3.4 Other chemical tests -- 24 11.4 -- 9 4.3 Cannabinoids 1.8 2 1.1 0.7 1 0.4 Other chemical tests -- 33 19.3 -- 12 7.2 LSD 3.8 7 2.4 1.2 4 0.9 Other chemical tests -- 28 18.0 -- 9 6.7 None (NCT)
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From page 51... ...
TABLE 20 Numbers and Percent of Living Volunteers Still in Service Admitted to Army Hospitals, by Years Since Testing and Response i Responded to No. Years Questionnaire Unable to located Since Testing Yes NOa No.
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TABLE 21 Results of Attempt to Interview Nonrespondents, by Chemical Group (Total) Results of attempt to interview nonrespondents No.
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TABLE 22 Response to Receipt of Questionnaire by 643 Interviewed Men Who Were on Special Assignment to Aberdeen Proving Ground, by Chemical Group (Total) Chemical Group No.
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From page 54... ...
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From page 55... ...
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From page 57... ...
NCT Exp.a Obs. OCT Exp.b 0 99 74.6 221 184.0 320 254.6 1 51 66.6 151 165.2 202 232.5 2 117 111.3 312 283.0 429 426.5 3-5 83 94.9 191 237.8 274 311.4 6-9 3 5.7 9 14.0 12 12.0 Total 353 353.1 884 884.0 1,237 1,237.0 Mean 1.81 2.01 1.81 2.01 1.81 1.95 Chi-square test summary: x2c 5 97 4.85 12.22 .
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From page 58... ...
Liveborn Ratio of Reported Offspring _ Observed Expected to Expected 0 320 246.3 1.30 1 202 211.9 0.95 2 429 406.4 1.06 3-5 274 349.9 0.78 6-9 12 22.6 0.53 Total Mean 1,237 2 X1 = 13.20a ~ < 0.001 1.81 2.09 a Mantel-Haenszel test of no children vs. one or more children with stratification on marital status and age in 1984.
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From page 59... ...
0005 0.935 ~ 0.05 ~ ~ > 0.01 ~ > 0.1 ~ > 0.1 a Includes children of unknown sex. b Mantel-Haenszel test with stratification on age (5-year groups)
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TABLE 29 Reported Use of Substances of Abuse Aluong All 4, 085 Respondents Used Used 10 or Never Used 1-9 Times More Times Not Stated Substance No.
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From page 61... ...
~ > 0.02 0.02 > ~ > 0.01 a Derived from age-specific reported use of LSD by subjects exposed to no chemicals. 3 Derived from age-specific reported use of LSD by subjects exposed to chemicals except LSD.
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