Possible Long-Term Health Effects of Short-Term Exposure To Chemical Agents, Volume 3 Final Report: Current Health Status of Test Subjects (1985) / Chapter Skim
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Appendix A Executive Summaries of Volumes 1 and 2
Appendix A Executive Summaries of Volumes 1 and 2
Pages 67-74
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From page 67... ...
The anticholinesterases are generally organophosphates; these are nerve agents resembling parathion. Major symptoms of low-level anticholinesterase exposure include salivation, increased sweating, contracted pupils, and bronchospasm.
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From page 68... ...
-[his might be considered, if reasonable suspicion develops, based on responses obtained in the ref- erenced morbidity study, that selected subjects experienced behavioral changes traceable in onset to experimental exposure to the anti-ChE agents. ANTICHOLINERGIC CHEMICALS No firm evidence has been seen that any of the anticholinergic test compounds surveyed produced long-range adverse human health effects in the doses used at Edgewood Arsenal.
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From page 69... ...
MORBIDITY An ongoing morbidity study among the test subjects is expected to provide a more complete understanding of the long-term consequences of exposure to anticholinergic and anticholinesterase chemicals. EXECUTIVE SUMMARY OF VOLUME 2 In 1980 the Board on Toxicology and Environmental Health Hazards of the National Research Council's Commission on Life Sciences began a program to evaluate the long-term health effects of chemical agents administered to military volunteers at the Army Chemical Center, Edgewood, Md., during the 1950s, 1960s, and 1970s.
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From page 70... ...
The specific charges to each panel were as follows: · To determine whether there was sufficient evidence to assess the likelihood that the test chemicals had had long-term health effects or delayed sequelae. · To determine on the basis of this evidence whether the chemicals, as administered, are likely to have produced such adverse effects in the test subjects.
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From page 71... ...
In general, the Committee found insufficient evidence to evaluate these chemicals, except mustard gas. Mustard gas is an experimental mutagen and human carcinogen at high doses.
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From page 72... ...
The Committee found no evidence of lasting ocular or respiratory effects in 99 volunteers exposed experimentally at Edgewood between 1958 and 1972 when subjects were evaluated 2 wk after cutaneous administration or inhalation of aerosol. Allergic contact dermatitis or hypersensitivity in these volunteers on re-exposure to CN is possible.
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From page 73... ...
The available data are insufficient to predict long-term health effects. The small number of exposures and the small number of subjects exposed to CR at low doses at Edgewood make the occurrence of demonstrable effects in these subjects unlikely.
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From page 74... ...
may provide further information on the current health status of these subjects.
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