Microbial Status and Genetic Evaluation of Mice and Rats Proceedings of the 1999 US/Japan Conference (2000) / Chapter Skim
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Development of the Mouse Model Dramatype for Human Clinical Benefit
Development of the Mouse Model Dramatype for Human Clinical Benefit
Pages 132-136
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From page 132... ...
In patients with so-called "smooth brain," or classical lissencephaly, the brain surface is basically smooth and without the usual cortical folds, which are important in normal brains to increase the surface area dramatically. Several mouse models share some of the characteristics of this disease.
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Our ultimate goals in conducting experiments with these animal models are to prevent and find a cure for this terrible disease. The reeler is a well-known mutant mouse found approximately half a century ago.
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infected pregnant mice with human influenza virus at midgestation and analyzed the neonatal brains. Interestingly, he found abnormal neuronal migration associated with reduced reelin expression (Fatemi and others 1999; Figure 2~.
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1995. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler.
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1999. Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates Tau phosphorylation.
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