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Microbial Status and Genetic Evaluation of Mice and Rats Proceedings of the 1999 US/Japan Conference (2000) / Chapter Skim
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Implication of Wild-derived Genes, Mitochondria, and Chromosomes in the Genetic Background of Mouse Models for Diseases and Biologic Functions
Pages 138-141

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From page 138...
... Obviously experimental analysis of these genes to include programmed mating can hardly be achieved in humans; therefore, it is advantageous to use experimental animals and, in particular, laboratory mice. For precise gene mapping in mice, several thousands of recently developed microsatellite DNA markers play an important role.
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From page 139...
... Their comparison between the incidence of diabetes and the introduced chromosome segments indicates the possible presence of three genes at 5' upstream of the H2- K-I region, already reported to be important in the control of diabetes. USE OF ASIAN WILD-DERIVED MITOCHONDRIA FOR STUDYING MOUSE BEHAVIOR In 1995, Kaneda and colleagues developed mitochondria congenic strains that carry mitochondria of either the Asian wild-derived Mus musculus musculus subspecies or the European wild-derived Mus spretus species (Kaneda and others 1995~.
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From page 140...
... Soon they expect to establish a set of CONS OMIC strains, which will be very useful for rapidly surveying one or more unknown gene/genes in a mutant mouse that expresses the phenotype at the whole body level. If any phenotypic difference is found between the donor and recipient strains and it is controlled by a single gene, it will be possible to readily identify the chromosome responsible for the phenotypic difference because these CONSOMIC strains prevent "noise" from genetic backgrounds.
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From page 141...
... 1981. Evolutionary relationships among five subspecies of Mus musculus based on restriction enzyme cleavage patterns of mitochondrial DNA.
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Key Terms

  • laboratory mice
  • mus musculus
  • wild mice
  • mouse strains
  • genetic background

  • consomic strains
  • asian wild
  • microsatellite dna
  • laboratory mouse
  • laboratory strains

  • mitochondrial dna
  • mitochondrial genome
  • physical performance
  • congenic strains
  • phenotypic difference

  • decreased physical
  • dna markers
  • european wild
  • genetic origin
  • antigenic specificities

  • recipient strains
  • programmed mating
  • markers play
  • experimental animals
  • genetic backgrounds

  • colleagues demonstrated
  • various recombinants
  • european subspecies
  • experimental analysis
  • genetically remote


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