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Microbial Status and Genetic Evaluation of Mice and Rats Proceedings of the 1999 US/Japan Conference (2000) / Chapter Skim
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Emerging Infections as a Cause of Concern
Pages 35-39

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From page 35...
... Even smallpox, which was officially eradicated in a great cooperative venture (for which Japanese scientist Esau Arita and others deserve a great share of the credit) , is something we argue about as a potential bioterrorist threat.
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From page 36...
... Such knowledge of the great, not yet fully tapped biodiversity of microorganisms requires us to avoid complacency and to understand that detection and diagnosis remain essential tools for control. RECOGNIZED THREATS Why might we be interested or concerned about emerging infections in laboratory animals?
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From page 37...
... Finally and very importantly is the opportunity to study chronic disease models, often perhaps in their natural or more nearly natural setting that may also closely resemble the human situation. Helicobacter is one example of such a model, and I suspect there are many other chronic disease models that can be found and demonstrated coming from our knowledge about existing infections or those newly introduced in laboratory animal colonies.
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From page 38...
... In addition, it might also be advisable to have some broad, perhaps more generic, strategies for looking at pathogen discovery, such as generic polymerase chain reaction or differential display methods that would more rapidly identify pathogens present in the population for which we cannot yet test. Briefly, gene expression and host markers also offer interesting possibilities.
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From page 39...
... For more information about DARPA, please feel free to browse our Web site (~. We are trying to develop new technologies and new approaches for the identification of infection and infectious pathogens that we hope will be useful in the future.
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Key Terms

  • emerging infections
  • animal colonies
  • animal models
  • laboratory animals
  • chronic disease

  • thymic virus
  • vast biodiversity
  • defense advance
  • mouse thymic
  • disease models

  • murine herpesvirus
  • spread rapidly
  • advance research
  • animal model
  • esau arita

  • risk associated
  • natural setting
  • possibility exists
  • japanese scientist
  • contaminated material

  • comparative study
  • officially eradicated
  • realistic situation
  • literally dozens
  • appropriate animal

  • avoid complacency
  • generic polymerase
  • polymerase chain
  • cooperative venture
  • chain reaction


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