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Microbial Status and Genetic Evaluation of Mice and Rats Proceedings of the 1999 US/Japan Conference (2000) / Chapter Skim
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Emerging Diseases in Mice and Rats
Pages 40-43

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From page 40...
... H HEPATICUS CONTAMINATION OF HUMAN TUMOR TISSUES PASSAGED IN IMMUNODIFICIENT MICE One aspect of cancer research at the Central Institute for Experimental Animals involves the collection of tumor tissues from patients and the subcutaneous inoculation into immunodeficient animals such as nude mice or mice with severe combined immunodeficiency (SCID)
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From page 41...
... hepaticus infection and the transplanted tissue was also contaminated. However, the bacterial count in each cryopreserved sample was low, the bacteria in the tissue were killed by the TABLE 1 Helicobacter hepaticus Contamination in Cryopreserved Human Tumor Xenografts in Immunodeficient Mice Year of Cryopreservation No.
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From page 42...
... hepaticus also caused persistent bacteremia in the same way that mouse hepatitis virus, Sendai virus, or Mycoplasma pulmonis infection causes viremia or bacteremia. As a result, the tumor and organ samples were contaminated.
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From page 43...
... Overtesting is of benefit only to testing facilities and some large-scale producers; it does not necessarily improve the quality of laboratory animals and animal experimentation, which is our objective. In the selection of test agents, I believe that additional consultation is necessary among researchers performing animal experiments, animal breeders, and testing facilities.
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Key Terms

  • laboratory animals
  • tumor tissues
  • immunodeficient mice
  • human tumor
  • microbiologic monitoring

  • animal experimentation
  • performed using
  • testing facilities
  • hepaticus infection
  • helicobacter hepaticus

  • hepaticus contamination
  • using immunodeficient
  • animal experiments
  • aids patients
  • infected immunodeficient

  • organisms subject
  • mycoplasma pulmonis
  • mice similarly
  • additional consultation
  • experimental animals

  • sendai virus
  • immunodeficient animals
  • caused persistent
  • hepaticus free
  • sterile conditions

  • nude mice
  • animals directly
  • establish individual
  • necessarily improve
  • categories described


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