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Microbial Status and Genetic Evaluation of Mice and Rats Proceedings of the 1999 US/Japan Conference (2000) / Chapter Skim
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Necessity of Genetic and Microbiologic Quality Network from the Pharmaceutical Industry's Perspective
Pages 77-84

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From page 77...
... ISSUES RELATED TO THE QUALITY OF OUTBRED MICE AND RATS Genetics: Genetic Drifting and Bottleneck in Outbred Stocks The genetic profile of a Wistar Hannover rat stock examined in 1993 is shown in Table 2. Because the HanIbm:WIST rat revealed a typical outbred gene frequency, we decided to use the rat for toxicology studies.
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From page 78...
... It is speculated that either the number of dams involved or the selection of breeding lines may have been incorrect, and the gene frequency of the hemoglobin beta chain reversed in the renewed colony. Customers complained to the breeder of significant changes in the sensitivity to chemicals and the baseline data on malformation.
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From page 79...
... We also do not know whether and to what extent the difference in gene frequency is within an acceptable range of diversity. Nevertheless, it is necessary to evaluate the genetic quality of outbred stock not by the stock or vendor name but by actual monitoring results.
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From page 80...
... 80 .= to AK o, A of .° a, ~ In In Go U. o lo ']
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From page 81...
... (Japan) Score Sendai virus Sialodacryoadenitis virus A A Pneumonia virus of mice A Mouse encephalomyelitis virus A Mouse adenovirus Minute virus of mice Kilham rat virus H-1 virus LCM virus Reo 3 virus Hantavirus Rat cytomegalovirus Mycoplasma pulmonis Mycoplasma arthritidis Clostridium piliforme (Tyzzer)
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From page 82...
... TABLE 5 Microbiologic Monitoring Items for Rats Minimum Requirement Recommended Sendai virus Sialodacryoadenitis virus Mycoplasma pulmonis Bordetella bronchiseptica Corynebacterium kutscheri Pasteurella pneumotropica Streptococcus pneumoniae Salmonella spp. Arthropods Helminths Eimeria spp.
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From page 83...
... Pneumonia virus of mice Mouse encephalomyelitis virus Minute virus of mice LCM virus Reo 3 virus Clostridium piliforme Bordetella bronchiseptica Citrobactor freundii 4280 beta-hemorrhytic streptococci Streptococcus pneumoniae Streptococcus moniliformis CAR bacillus Pseudomonas aeruginosa Klossiella spp. Encephalitozoon cuniculi Toxoplasma gondii Other flagellates
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From page 84...
... Novartis requests reference organizations to provide: > Evaluation standard for genetic drifting of outbred stock > Harmonized minimum health profile > Supply of reference substances REFERENCES Katoh, H., S Wakana, S
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Key Terms

  • gene frequency
  • genetic drifting
  • quality network
  • outbred stock
  • monitoring items

  • microbiologic monitoring
  • reference substances
  • breeding sites
  • minimum health
  • toxicology studies

  • reference organizations
  • outbred mice
  • wistar hannover
  • microbiological associates
  • sendai virus

  • genetic monitoring
  • checking methods
  • rats supplied
  • expects global
  • selected profiles

  • breeding scheme
  • avoid genetic
  • monitoring results
  • laboratory animal
  • using rats

  • animal quality
  • animal services
  • hannover rat
  • global vendors
  • survey granted


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