Capturing the Full Power of Biomaterials for Military Medicine
Report of a Workshop
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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.
This study was supported by Contract DOD-4996 between the National Academy of Sciences and the Department of Defense. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the views of the organizations or agencies that provided support for the project.
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COMMITTEE ON CAPTURING THE FULL POWER OF BIOMATERIALS FOR MILITARY MEDICAL NEEDS
JAMES M. ANDERSON,
Case Western Reserve University, Cleveland, Ohio,
Chair
GARY W. CLEARY,
Corium International, Inc., Redwood City, California
ERIK A. HENCHAL,
U.S. Army Medical Research Institute of Infectious Disease, Ft. Detrick, Maryland
JOHN B. HOLCOMB,
U.S. Army Institute for Surgical Research, Ft. Sam Houston, Texas
JEFFREY O. HOLLINGER,
Carnegie Mellon University, Pittsburgh, Pennsylvania
ALAN LETTON,
Polymerix Corp., Piscataway, New Jersey
ARUNA NATHAN,
Ethicon, Inc., Somerville, New Jersey
JAQUES REIFMAN,
U.S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland
JAMES SCHEIRER,
Robert Wood Johnson Medical School, New Brunswick, New Jersey
PETER P. TOLIAS,
Ortho-Clinical Diagnostics, a Johnson and Johnson company, Raritan, New Jersey
ROBERT H. VANDRE,
U.S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland
Staff
TONI MARECHAUX, Study Director
MARTA VORNBROCK, Research Assistant
BOARD ON MANUFACTURING AND ENGINEERING DESIGN
PAMELA A. DREW,
The Boeing Company, Seattle, Washington,
Chair
CAROL L.J. ADKINS,
Sandia National Laboratories, Albuquerque, New Mexico
GREGORY AUNER,
Wayne State University, Detroit, Michigan
THOMAS W. EAGAR,
Massachusetts Institute of Technology, Cambridge
ROBERT E. FONTANA, JR.,
Hitachi Global Storage Technologies, San Jose, California
PAUL B. GERMERAAD,
Intellectual Assets, Inc., Saratoga, California
ROBERT M. HATHAWAY,
Oshkosh Truck Corporation, Oshkosh, Wisconsin
RICHARD L. KEGG,
Milacron, Inc. (retired), Cincinnati, Ohio
PRADEEP K. KHOSLA,
Carnegie Mellon University, Pittsburgh, Pennsylvania
JAY LEE,
University of Wisconsin, Milwaukee
DIANA L. LONG,
Robert C. Byrd Institute for Flexible Manufacturing, South Charleston, West Virginia
JAMES MATTICE,
Universal Technology Corporation, Dayton, Ohio
MANISH MEHTA,
National Center for Manufacturing Sciences, Ann Arbor, Michigan
ANGELO M. NINIVAGGI, JR.,
Plexus, Nampa, Idaho
JAMES B. O'DWYER,
PPG Industries, Allison Park, Pennsylvania
HERSCHEL H. REESE,
Dow Corning Corporation, Midland, Michigan
H.M. REININGA,
Rockwell Collins, Cedar Rapids, Iowa
LAWRENCE RHOADES,
Extrude Hone Corporation, Irwin, Pennsylvania
JAMES B. RICE, JR.,
Massachusetts Institute of Technology, Cambridge
ALFONSO VELOSA III,
Gartner, Inc., Tucson, Arizona
JACK WHITE,
Altarum, Ann Arbor, Michigan
JOEL SAMUEL YUDKEN,
AFL-CIO, Washington, D.C.
Staff
TONI MARECHAUX, Director
NATIONAL MATERIALS ADVISORY BOARD
JULIA M. PHILLIPS,
Sandia National Laboratories, Albuquerque, New Mexico,
Chair
JOHN ALLISON,
Ford Research Laboratories, Dearborn, Michigan
PAUL BECHER,
Oak Ridge National Laboratory, Tennessee
BARBARA D. BOYAN,
Georgia Institute of Technology, Atlanta
DIANNE CHONG,
The Boeing Company, St. Louis, Missouri
FIONA DOYLE,
University of California, Berkeley
GARY FISCHMAN,
Biomedical Applications of Materials Consultant, Palatine, Illinois
KATHARINE G. FRASE,
IBM, Hopewell Junction, New York
HAMISH L. FRASER,
Ohio State University, Columbus
JOHN J. GASSNER,
U.S. Army Natick Soldier Center, Massachusetts
THOMAS S. HARTWICK,
TRW (retired), Snohomish, Washington
ARTHUR H. HEUER,
Case Western Reserve University, Cleveland, Ohio
ELIZABETH HOLM,
Sandia National Laboratories, Albuquerque, New Mexico
FRANK E. KARASZ,
University of Massachusetts, Amherst
SHEILA F. KIA,
General Motors Research and Development Center, Warren, Michigan
CONILEE G. KIRKPATRICK,
HRL Laboratories, Malibu, California
ENRIQUE J. LAVERNIA,
University of California, Davis
TERRY LOWE,
Los Alamos National Laboratory, New Mexico
HENRY J. RACK,
Clemson University, Clemson, South Carolina
LINDA SCHADLER,
Rensselaer Polytechnic Institute, Troy, New York
JAMES C. SEFERIS,
University of Washington, Seattle
T.S. SUDARSHAN,
Materials Modification, Inc., Fairfax, Virginia
JULIA WEERTMAN,
Northwestern University, Evanston, Illinois
Staff
TONI MARECHAUX, Director
Preface
This document is the result of a technology planning process undertaken by the new Center for Military Biomaterials Research and the National Academies to begin closing the gap between available biomaterials-related technologies and the military’s needs. The critical first step in this process was the organization of a workshop, held in Iselin, New Jersey, on February 2-4, 2004. To ensure that the directions taken would be aligned with the military’s needs, participants included 15 senior U.S. Army officers and scientists who are experts in the health care needs of warfighters. Participants also included 27 industrial scientists and business leaders who provided the state of the art in commercial biomaterial product developments. The third constituency was the 40 academicians who presented the most recent basic and applied research concepts in the field.
The principal goal of the workshop was to explore a comprehensive approach to bringing new biomaterials technologies into service to fulfill the military's medical needs as early as possible. The workshop was intended to involve scientific, clinical, and business leaders from the field of medical biomaterials as knowledge sources and guides interacting with military scientists, clinicians, and program planners. The content was intended to address both the science contributing to biomaterials-based products and the corporate culture of technology companies working in biomaterials areas.
The technology development roadmap that is detailed here is the first step for enabling the military to modify and enhance its existing research and development programs in order to take best advantage of academic-based and corporate advances in biomaterials technology. A near-term benefit of implementing this roadmap will be advances in combat casualty care through focused attention on targeted modification of emerging industrial products to increase their suitability for use on the battlefield. Through the implementation of the technology development plan articulated in this roadmap, the Army’s interests will be connected with a comprehensive network of scientific leaders, core competency laboratories, and innovative companies.
This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the National Research Council's (NRC's) Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process.
The authors wish to thank the following individuals for their participation in the review of this report:
Pat Black, Picatinny Arsenal, U.S. Army
Gary Fischman, consultant to the biomaterials industry
Michael Helmus, Boston Scientific Corporation
Joshua Jacobs, Rush Medical College
Julie Swain, consultant to the Food and Drug Administration
Ranji Vaidyanathan, Advanced Ceramics Research, Inc.
Although the reviewers listed above have provided many constructive comments and suggestions, they were not asked to endorse the views expressed, nor did they see the final draft of the report before its release. The review of this report was overseen by Robert Frosch of Harvard University. Appointed by the NRC, Dr. Frosch was responsible for making certain that an independent examination of this report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this report rests entirely with the authoring committee and the institution.
The committee also acknowledges the invaluable contributions of Pablo Whaley, Michele Iacoletti, and Shara Williams, interns at the National Academies, in the preparation of this report. Barbara M. Boyan also greatly assisted the work of the committee through her participation in many of the committee's activities as liaison to the National Materials Advisory Board.
James M. Anderson, Chair
Committee on Capturing the Full Power of Biomaterials for Military Medical Needs