SEX DIFFERENCES AND IMPLICATIONS FOR TRANSLATIONAL NEUROSCIENCE RESEARCH
WORKSHOP SUMMARY
Diana E. Pankevich, Theresa Wizemann, and Bruce M. Altevogt, Rapporteurs
INSTITUTE OF MEDICINE
OF THE NATIONAL ACADEMIES
THE NATIONAL ACADEMIES PRESS
Washington, D.C.
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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.
This project was supported by contracts between the National Academy of Sciences and the Alzheimer’s Association; AstraZeneca Pharmaceuticals, Inc.; CeNeRx Biopharma; the Department of Health and Human Services’ National Institutes of Health (NIH, Contract Nos. N01-OD-4-213) through the National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, National Eye Institute, NIH Blueprint for Neuroscience Research, National Institute of Mental Health, and National Institute of Neurological Disorders and Stroke; Eli Lilly and Company; GE Healthcare, Inc.; GlaxoSmithKline, Inc.; Johnson & Johnson Pharmaceutical Research and Development, LLC; Merck Research Laboratories; the National Multiple Sclerosis Society; the National Science Foundation (Contract No. OIA-0753701); the Society for Neuroscience; and Wyeth Research, Inc. The views presented in this publication are those of the editors and attributing authors and do not necessarily reflect the view of the organizations or agencies that provided support for this project.
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Suggested citation: IOM (Institute of Medicine). 2011. Sex differences and implications for translational neuroscience research: Workshop summary. Washington, DC: The National Academies Press.
THE NATIONAL ACADEMIES
Advisers to the Nation on Science, Engineering, and Medicine
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WORKSHOP ON SEX DIFFERENCES AND IMPLICATIONS FOR TRANSLATIONAL NEUROSCIENCE RESEARCH PLANNING COMMITTEE*
RAE SILVER (Cochair),
Columbia University
STEVIN H. ZORN (Cochair),
Lundbeck USA
TIMOTHY COETZEE,
National Multiple Sclerosis Society
PAUL M. HOFFMAN,
North Florida/South Georgia Veterans Health System
CHI-MING LEE,
AstraZeneca Pharmaceuticals
RICHARD NAKAMURA,
National Institute of Mental Health
KATHIE L. OLSEN,
Association of Public and Land-Grant Universities
AMEETA PAREKH,
Food and Drug Administration
VIVIAN W. PINN,
National Institutes of Health
Study Staff
BRUCE M. ALTEVOGT, Project Director,
IOM
SARAH L. HANSON, Associate Program Officer (until June 2010)
LORA K. TAYLOR, Senior Project Assistant, IOM
INSTITUTE OF MEDICINE FORUM ON NEUROSCIENCE AND NERVOUS SYSTEM DISORDERS*
ALAN LESHNER (Chair),
American Association for the Advancement of Science
HUDA AKIL,
University of Michigan
MARC BARLOW,
GE Healthcare, Inc.
MARK BEAR,
Massachusetts Institute of Technology
DAVID BREDT,
Eli Lilly and Company
DANIEL BURCH,
CeNeRx Biopharma
DENNIS CHOI,
Emory University
TIMOTHY COETZEE,
National Multiple Sclerosis Society
DAVID COHEN,
Columbia University
EMMELINE EDWARDS,
NIH Neuroscience Blueprint (since February 2010)
RICHARD FRANK,
GE Healthcare, Inc.
JOHN GRIFFIN,
Johns Hopkins University School of Medicine
MYRON GUTTMAN,
National Science Foundation (since June 2010)
RICHARD HODES,
National Institute on Aging
KATIE HOOD,
Michael J. Fox Foundation for Parkinson’s Research
STEVEN E. HYMAN,
Harvard University
THOMAS INSEL,
National Institute of Mental Health
STORY LANDIS,
National Institute of Neurological Disorders and Stroke
HUSSEINI MANJI,
Johnson & Johnson Pharmaceutical Research and Development, LLC
EVE MARDER,
Brandeis University
DAVID MICHELSON,
Merck Research Laboratories
JONATHAN MORENO,
University of Pennsylvania School of Medicine
MICHAEL OBERDORFER,
NIH Neuroscience Blueprint (until January 2010)
KATHIE L. OLSEN,
Association of Public and Land-Grant Universities
ATUL PANDE,
GlaxoSmithKline, Inc.
MENELAS PANGALOS,
Pfizer Inc
STEVEN PAUL,
Weill Cornell Medical College
WILLIAM POTTER,
FNIH Neuroscience Biomarker Steering Committee
PAUL SIEVING,
National Eye Institute
RAE SILVER,
Columbia University
WILLIAM THIES,
Alzheimer’s Association
NORA VOLKOW,
National Institute on Drug Abuse
KENNETH WARREN,
National Institute on Alcohol Abuse and Alcoholism
FRANK YOCCA,
AstraZeneca Pharmaceuticals
STEVIN H. ZORN,
Lundbeck USA
CHARLES ZORUMSKI,
Washington University School of Medicine
IOM Staff
BRUCE M. ALTEVOGT, Forum Director
SARAH L. HANSON, Associate Program Officer (until June 2010)
DIANA E. PANKEVICH, Associate Program Officer (since October 2010)
LORA K. TAYLOR, Senior Project Assistant
ANDREW POPE, Director,
Board on Health Sciences Policy
Reviewers
This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the National Research Council’s Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the process. We wish to thank the following individuals for their review of this report:
Katja Brose, Neuron
Jean Merrill, EMD Serono Research Institute, Inc.
Morgan Sheng, Genentech, Inc.
Kimberly Yonkers, Yale University
Although the reviewers listed above have provided many constructive comments and suggestions, they did not see the final draft of the report before its release. The review of this report was overseen by Dr. William E. Bunney, University of California, Irvine, Distinguished Professor. Appointed by the Institute of Medicine, he was responsible for making certain that an independent examination of this report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this report rests entirely with the authoring committee and the institution.