NATIONAL ACADEMY OF SCIENCES
Colloquium Series
In 1991, the National Academy of Sciences inaugurated a series of scientific colloquia, five or six of which are scheduled each year under the guidance of the NAS Council’s Committee on Scientific Programs. Each colloquium addresses a scientific topic of broad and topical interest, cutting across two or more of the traditional disciplines. Typically two days long, colloquia are international in scope and bring together leading scientists in the field. Papers from colloquia are published in the Proceedings of the National Academy of Sciences (PNAS).
National Academy of Sciences Colloquium Arnold and Mabel Beckman Center, Irvine
The Neurobiology of Pain
December 11–13, 1998
PROGRAM
Friday, December 11, 1998
Introduction
Ronald Dubner, Colloquium Organizer
Session I: Channels
Chair and Discussion Leader John Hunter, Department of Analgesia, Roche Bioscience
Stephen G. Waxman, Department of Neurology, Yale University School of Medicine
Sodium Channels and the Pathophysiology of Pain
Michael Gold, Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School
TTX-R INaand Inflammatory Hyperalgesia
Daniel Weinreich, Department of Pharmacology and Experimental Therapeutics, University of Maryland, School of Medicine
Which Potassium Channels Keep Vagal Afferent Neurons Mellow?
Discussant Peter McNaughton, Department of Physiology, King’s College London
Heat-Activated Ion Currents in Nociceptors–Transduction and Sensitization
Session II: Receptors
Chair and Discussion Leader Patrick Mantyh, Department of Preventive Sciences, School of Dentistry, University of Minnesota
Amy B. MacDermott, Department of Physiology and Cellular Biophysics and Center for Neurobiology and Behavior, Columbia University
AMPA and Kainate Receptor Expression by DRG Neurons in Culture
Edwin W. McCleskey, Vollum Institute, Oregon Health Sciences University
The Role of Sensory Modality-Selective Gene Transcription in Opioid Analgesia
Michael W. Salter, Programmes in Brain and Behavior and Cell Biology, Hospital for Sick Children, and Department of Physiology, University of Toronto
NMDA Receptors and Src in Synaptic Plasticity
Discussant Edward R. Perl, Department of Physiology, University of North Carolina School of Medicine, Chapel Hill
Receptor Expression and Regulation as Mechanisms Underlying Pain and Pain Pathology
Saturday, December 12, 1998
Introduction
Michael Gold, Colloquium Organizer
Tribute to John Liebeskind
Gregory Terman, Department of Anesthesiology, University of Washington, Seattle
Session III A: Systems and Imaging
Chair and Discussion Leader Donna Hammond, Anesthesia and Critical Care, University of Chicago
William D. Willis, Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston, Texas
Evidence for a Visceral Pain Pathway in the Dorsal Column of the Spinal Cord
Tony L. Yaksh, Anesthesiology Research Laboratory, University of California
The Spinal Biology in Humans and Animals of Pain States Generated by Persistent Small Afferent Input
Discussant Gerald Gebhart, Department of Pharmacology, University of Iowa
Session III B: Systems and Imaging
Chair and Discussion Leader James Campbell, Department of Neurology, Johns Hopkins University Medical School
Howard Fields, University of California, San Francisco
Neuropeptides and Brainstem Pain Modulating Circuits
Kenneth L. Casey, Neurological Service, Veterans Administration Medical Center, Ann Arbor, Michigan
Forebrain Mechanisms of Nociception and Pain: Analysis through Imaging
Discussant M. Catherine Bushnell, McGill University, Montreal
What Are the Essential Cerebral Components?
Session IV: Growth Factors and Cytokines
Chair and Discussion Leader Kenneth Hargreaves, Department of Endodontics, University of Texas Health Sciences Center
William Snider, Department of Neurology, Washington University Medical Center
Trophic Factor Regulation of Nociceptor Development
Lorne M. Mendell, Department of Neurobiology and Behavior, State University of New York at Stony Brook
Neurotrophins and Pain
Linda R. Watkins, Department of Psychology, University of Colorado at Boulder
Immune-to-Brain Communication: Implications for Sickness and Pain
Discussant Stephen B. McMahon, Neuroscience Research Centre, King’s College London
Multiple Trophic Factor Influences on Nociceptive System
Saturday, December 12, 1998
Session V: Development and Plasticity
Chair and Discussion Leader Ronald Dubner, Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School
Maria Fitzgerald, Department of Anatomy and Developmental Biology, University College London
Postnatal Changes in Dorsal Horn Cell Activity–The Development of Spinal Sensory Processing
Clifford J. Woolf, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School
Signal- and Activity-Dependent Plasticity in the Somatosensory System–Unraveling the Cellular and Molecular Mechanisms of Pain
David J. Mayer, Department of Anesthesiology, Medical College of Virginia
Cellular Mechanisms of Hyperalgesia and Morphine Tolerance and Their Interactions
Discussant Gary Bennett, Department of Neurology, Allegheny University, Philadelphia
The Revolution in Pain Research
Banquet for Colloquium Attendees
Banquet Speaker John Loeser, Department of Neurological Surgery and Anesthesiology, University of Washington Medical Center
Sunday, December 13, 1998
Session VI: Molecular Genetics
Chair and Discussion Leader Charles Inturrisi, Department of Pharmacology, Cornell University Medical College
Allan Basbaum, Department of Anatomy, University of California, San Francisco
The Neurochemistry of Acute and Persistent Pain
Michael A. Moskowitz, Department of Neurosurgery and Neurology, Massachusetts General Hospital
Migraine Pathophysiology and Treatment Mechanisms
Jeffrey Mogil, Department of Psychology, University of Illinois at Urbana
The Genetics of Pain and Pain Inhibition: From Mice to Molecules
George Uhl, National Institute on Drug Abuse, National Institutes of Health
The Mu Opiate Receptor as a Model Gene for Individual Differences in Pain and Pain Modulation
Discussant Frank Porreca, Department of Pharmacology, University of Arizona Health Sciences Center
Antisense Oligodeoxynucleotides against the TTX-Resistant Sodium Channel, PN3, Prevent and Reverse Chronic, Inflammatory and Neuropathic Pain in the Rat
List of Attendees
Lisa Aimone
George S. Aitken, Delta Medical Dental Centre
David J. Anderson, California Institute of Technology
David Andrew, Barrow Neurological Institute
K. Roger Aoki, Allergan
Dietrich Arndts, Boehringer Ingelheim
Ronald K. Ashley
Laura Audell
Victor Babenko, Aalborg University
Leif K. Bakland, Loma Linda University School of Dentistry
Allan Basbaum, University of California, San Francisco
Gary Bennett, MCP Hahnemann University
Jack M. Berger, University of Southern California School of Medicine
Scott Bowersox, Elan Pharmaceuticals
Walter Bowles, University of Minnesota
Robert Brennan, University of California, Los Angeles
Cathy Bushnell, McGill University
James Campbell, John Hopkins University
Yuqing Cao, University of California, San Francisco
Ken Casey, University of Michigan
Lin Chang, University of California, Los Angeles
Jenny Chen, University of California, Los Angeles
Zhou-Feng Chen, California Institute of Technology
Ken Chow, Allergan
Glenn Clark, University of California, Los Angeles
Patricia Claude, University of Texas, Health Science Center at San Antonio
Amy D. Clegg
Joseph R. Cohen, University of California, Los Angeles
Sean P. Cook, Oregon Health Sciences University-Vollum Institute, L-474
Santosh Coutinho, University of California, Los Angeles
Marie Csete, California Institute of Technology
Minglei Cui, Allergan
Bennet Davis
Xinzhong Dong, California Institute of Technology
Emma Dormand, California Institute of Technology
Ronald Dubner, University of Maryland Dental School
Helena Ennes, University of California, Los Angeles
Mark Erlander, RW Johnson Pharmalogical Research Institute
Stephen EspitiaJack L. Feldman, University of California,
Los Angeles
Howard Fields, University of California, San Francisco
Maria Fitzgerald, University College London
Christopher M. Flores, University of Texas
Nicholas Fuller, Cedars-Sinai Medical Center-The Pain Center
Gerald Gebhart, University of Iowa
Daniel W. Gil, Allergan, Inc.
Michael Gold, University of Maryland Dental School
Jay A. Goldstein
Robert Grimm
Paul Haerich, Loma Linda University
Aldric Hama
Donna Hammond, University of Chicago
Michael Hans
Kenneth Hargreaves, University of Texas, Health Science Center at San Antonio
Michael Hayward, Oregon Health Sciences University
Standiford Helm
David Helton, B. Braun Medical Inc.
Michael A. Henry, University of Colorado Health Science Center
H. Haydon Hill, Rehabilitation Medicine Associates
Dianne Hodges, CoCensys, Inc.
Lynda C. Honour
John Hunter, Roche
Victor Ilyin, CoCensys, Inc
Charles Inturrisi, Cornell University
Douglass L. Jackson, University of Washington-School of Dentistry
Stephen W. Jenkins, Allergan, Inc.
Russell Johnson, University of California, Los Angeles
Gerald J. Jonak, Dupont
Wade Kingery, Veterans Adminstration
Cheryl Kitt, National Institutes of Health
Beat Knusel, Allergan, Inc
Brad Kolls
Chris Konkoy
Lawrence Kruger, University of California, Los Angeles Medical Center
Nancy Lan, CoCensys Inc.
Letitia Lau
Jacqueline E. Lee, University of Colorado, Boulder
Julia Liebeskind
Wei-Jen Lin, Allergan
John Loeser
Lin Luo, RW Johnson Pharmalogical Research Institute
Z. David Luo, University of California, San Diego
Kabirullah Lutfy, University of California, Los Angeles
Amy MacDermott, Columbia University
Nigel T. Maidment, University of California, Los Angeles
Celine Maillot, West Los Angeles V.A. Medical Center
Phil Malan, The University of Arizona
Mario G. Maldonado
Annika Malmberg, University of California, San Francisco
Corinne Manetto, Cedars-Sinai Comprehensive Cancer Center
Patrick Mantyh, University of Minnesota
Jianren Mao, VCU
Wendy Martin, Glaxo Wellcome, Inc.
William J. Martin, University of California, San Francisco
Juan Carlos Marvizon, University of California, Los Angeles
Emeran A. Mayer, University of California, Los Angeles, Division of Digestive Diseases
Ed McCleskey, Oregon Health Sciences University
Steve McMahon, King’s College London
Peter McNaughton, King’s College London
Lorne Mendell, State University of New York, Sunny Brook
Robert L. Merrill, University of California, Los Angeles School of Dentistry
Somsak Mitrirattanakul, University of California, Los Angeles
Jeffrey Mogil, University of Illinois at Urbana Champaign
Derek Molliver, Washington University of Saint Louis
Carlo V. Morpurgo
Mike Moskowitz, Harvard University
Million Mulugeta, West Los Angeles V.A. Medical Center
Alexander Nemirovsky
John K. Neubert
Alan Newman
Michael Ossipov, University of Arizona
A. Pace-Floridia
Pamela Pierce Palmer, University of California, San Francisco
Ed Perl, University of North Carolina
Karla Petersen, University of California, San Francisco
Frank Porreca, University of Arizona
Joshua P. Prager, California Pain Medical Center
Robert W. Presley, Pain Care Specialists
Steven Graff Radford, University of California, Los Angeles
John L. Reeves II, University of California, Los Angeles
Ke Ren, University of Maryland
Linda J. Rever
Steven Richeimer, University of California, Davis
Ruth Riley, University of California, San Francisco
Susan Roche, Orofacial Pain Management Clinic
Gary G. Rosengarten, The Pain Center, CSMC
Mike Salter, University of Toronto
Christine Sang
Harry Sernaker, University of Maryland
Seth Silbert, Oregon Health Sciences University-Vollum Inst.
William Snider, Washington University
Michael C. Son
Linda S. Sorkin, University of California, San Diego
Athena Spanoyannis, Allergan Inc.
Igor Spigelman, University of California, Los Angeles, School of Dentistry
Yvette Tache, University of California, Los Angeles
Brad Taylor, University of California, San Francisco
Edgar Tenorio, Elan Pharmaceuticals
Gregory Terman
Arnold Towe, University of Washington
Jodie Trafton, University of California, San Francisco
George Uhl, National Institute of Health
Clayton Varga, PRI
Douglas R. Wall
Wendy M. Walwyn, University of California
John Y.-X. Wang, Elan Pharmaceuticals
Yu Hua Wang, University of California, Los Angeles
Linda Watkins, University of Colorado
Steve Waxman, Yale University
Jen Yu Wei, University of California, Los Angeles, School of Medicine
Daniel Weinreich, University of Maryland
Ursula Wesselman, Johns Hopkins University
Larry A. Wheeler, Allergan
Joan Wilentz, National Institute of Dental and Cranofacial Research
William Willis, University of Texas Medical Branch
Steven P. Wilson, University of South Carolina School of Medicine
Richard Woodward, Cocensys Inc.
Clifford Woolf, Harvard University
Tony Yaksh, University of California, San Diego
Jen Yu, University of California, Irvine Medical Center
P ROCEEDINGS OF THE N ATIONAL A CADEMY OF S CIENCES OF THE U NITED S TATES OF A MERICA
Table of Contents
Papers from a National Academy of Sciences Colloquium on The Neurobiology of Pain